Ranakinin
Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion.
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- CAS. Nr.: 139446-71-2
- Formel: C62H95N17O15S
- Molecular Weight:1350.59
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Biologische Aktivität
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NK1R |
PLC |
Ranakinin potently binds to and inhibits the binding of selective tachykinin NK1 receptor radioligands to membrane binding sites in rat submandibular glands, with an IC50 of 1.6 nM[1].
Ranakinin (10-9-10-5 M; 20 sec) stimulates the production of IP3, IP2 and IP1 in a time- and dose-dependent manner, and decreases the concentrations of PIP2 and PIP in a time- and dose-dependent manner, with no effect on PI levels, in myo-[3H]inositol-prelabeled adrenal tissues of Rana ridibunda[2].
Ranakinin (10-5 M; 20 min) doubles the secretions of corticosterone and aldosterone from perfused adrenal explants of Rana ridibunda[2].
Ranakinin (at different competitor concentrations; incubated for 60 min at 25 °C) binds to bufokinin (bNK1) receptors in intestinal smooth muscle membrane homogenates of Bufo marinus, with an IC50 of 2.8 nM, exhibiting high binding affinity almost comparable to that of bufokinin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 139446-71-2
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Molecular Weight 1350.59
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Formel C62H95N17O15S
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Sequence
Lys-Pro-Asn-Pro-Glu-Arg-Phe-Tyr-Gly-Leu-Met-NH2
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Sequence Shortening
KPNPERFYGLM-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. O'Harte F, et al. Ranakinin: a novel NK1 tachykinin receptor agonist isolated with neurokinin B from the brain of the frog Rana ridibunda. J Neurochem. 1991 Dec;57(6):2086-91. [Content Brief]
[2]. Kodjo MK, et al. Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. Endocrinology. 1998;139(2):505-512. [Content Brief]
[3]. Liu L, et al. Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2005;69(2):329-338. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ranakinin Related Classifications
HY-P2139 Related Classifications
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