Saccharolactone
Based on 1 publication(s) in Google Scholar
Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM).
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- CAS. Nr.: 389-36-6
- Formel: C6H8O7
- Molecular Weight:192.12
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Saccharolactone
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Biologische Aktivität
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CYP1A2 <4 mM (IC50) |
CYP2D6 <4 mM (IC50) |
CYP3A4 <4 mM (IC50) |
CYP2C8 <4 mM (IC50) |
Chemical Information
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CAS. Nr. 389-36-6
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Molecular Weight 192.12
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Formel C6H8O7
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SMILES
OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Enzyme Inhib Med Chem
Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. [Abstract]2024 Dec;39(1):2387415. PMID: 39140677
Reinheit & Dokumentation
Verweise
[1]. Macfadyen A, et al. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. Hepatology. 1989 Apr;9(4):552-6. [Content Brief]
[2]. Behera D, et al. Effect of Saccharolactone on CYP-mediated Metabolism of Xenobiotics. Drug Metab Bioanal Lett. 2023;16(2):121-132. [Content Brief]
[3]. Oleson L, et al. Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. J Pharm Pharmacol. 2008 Sep;60(9):1175-82. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Saccharolactone Related Classifications
HY-153875 Related Classifications
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