ST-1006
Based on 1 Customer Validation
ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.55%
- CAS. Nr.: 1196994-11-2
- Formel: C16H20Cl2N6
- Molecular Weight:367.28
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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H4 receptor 7.94 (pKi) |
ST-1006 (10 μM) is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) suppresses FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1]
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Dosage:1-100 mg/kg
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Administration:Subcutaneous injection
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Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
Chemical Information
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CAS. Nr. 1196994-11-2
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Appearance Solid
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Molecular Weight 367.28
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Formel C16H20Cl2N6
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Color White to off-white
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SMILES
ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (340.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [Content Brief]
[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7227 mL | 13.6136 mL | 27.2272 mL | 68.0680 mL |
| 5 mM | 0.5445 mL | 2.7227 mL | 5.4454 mL | 13.6136 mL | |
| 10 mM | 0.2723 mL | 1.3614 mL | 2.7227 mL | 6.8068 mL | |
| 15 mM | 0.1815 mL | 0.9076 mL | 1.8151 mL | 4.5379 mL | |
| 20 mM | 0.1361 mL | 0.6807 mL | 1.3614 mL | 3.4034 mL | |
| 25 mM | 0.1089 mL | 0.5445 mL | 1.0891 mL | 2.7227 mL | |
| 30 mM | 0.0908 mL | 0.4538 mL | 0.9076 mL | 2.2689 mL | |
| 40 mM | 0.0681 mL | 0.3403 mL | 0.6807 mL | 1.7017 mL | |
| 50 mM | 0.0545 mL | 0.2723 mL | 0.5445 mL | 1.3614 mL | |
| 60 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 1.1345 mL | |
| 80 mM | 0.0340 mL | 0.1702 mL | 0.3403 mL | 0.8508 mL | |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2723 mL | 0.6807 mL |
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