B-Raf IN 19
B-Raf IN 19 (compound 31) is a BRAF inhibitor that inhibits BRAF(WT) and BRAF(V600E) (IC50: 0.57 μM and 0.28 μM, respectively). B-Raf IN 19 inhibits MAPK signaling in melanoma cells.
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- CAS. Nr.: 708218-62-6
- Formel: C20H15NO3S3
- Molecular Weight:413.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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BRAFWT 0.57 μM (IC50) |
BRafV600E 0.28 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.28 μM
Compound: 31
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Inhibition of human 6x-His tagged BRAF V600E mutant expressed in Sf9 cells by ELISA based kinase assay
Inhibition of human 6x-His tagged BRAF V600E mutant expressed in Sf9 cells by ELISA based kinase assay
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[PMID: 22537109] |
| Sf9 | IC50 |
0.57 μM
Compound: 31
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Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assay
Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assay
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[PMID: 22537109] |
Chemical Information
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CAS. Nr. 708218-62-6
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Molecular Weight 413.53
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Formel C20H15NO3S3
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SMILES
O=S(NC1=CC(SC2=CC=CC=C2)=C(C3=C1C=CC=C3)O)(C4=CC=CS4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
B-Raf IN 19 Related Classifications
HY-155942 Related Classifications
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