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Art. -Nr.: HY-190795

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TAP-05

TAP-05 is a thiazole small molecule with inhibitory activity against parasites. TAP-05 inhibits the growth of Toxoplasma gondii and Leishmania infantum. TAP-05 can be used for research on toxoplasmosis and visceral leishmaniasis.

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CAS. Nr.: 16085-74-8
Formel: C₁₅H₁₁N₅O₂S
Molecular Weight:325.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TAP-05 Chemical Structure

CAS. Nr.: 16085-74-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Innate ImmunityParasitic InfectionOthers

Innate Immunity

TAP-05 (48 h) is cytotoxic to BALB/c peritoneal macrophages, with a CC₅₀ of 2.95 μM^[2].

Parasitic Infection

TAP-05 (72 h) inhibits intracellular tachyzoites of Toxoplasma gondii RH-2F1 in HFF cells, with an EC₅₀ of 0.264 μM and a selectivity index of 183.26^[1].
TAP-05 (0.264 μM; 48 h) induces cytoplasmic vacuolation, reduced ultrastructural signs of tachyzoite division, and occasional Golgi apparatus alterations in Toxoplasma gondii-infected HFF cells^[1].
TAP-05 (48 h) inhibits the growth of Leishmania infantum promastigotes with an IC₅₀ of 0.42 μM and a promastigote selectivity index of 7.07^[2].

Others

TAP-05 (72 h) exhibits low cytotoxicity against HFF cells, with a CC₅₀ of 48.44 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 16085-74-8
Molecular Weight 325.35
Formel C₁₅H₁₁N₅O₂S
SMILES

O=[N+](C1=CC(C2=CSC(N/N=C/C3=NC=CC=C3)=N2)=CC=C1)[O-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dias IO, et al. Highly Selective Thiazole Derivatives as Promising Anti-Toxoplasma gondii Agents. ACS Omega. 2026 Sep 24;11(39):59807-59814. [Content Brief]

[2]. de Oliveira VVG, et al. Study of in vitro biological activity of thiazoles on Leishmania (Leishmania) infantum. Journal of global antimicrobial resistance. 2020 Sep;22:414-421. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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