Terreic acid
Based on 1 publication(s) in Google Scholar
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM.
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- CAS. Nr.: 121-40-4
- Formel: C7H6O4
- Molecular Weight:154.12
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) Terreic acid
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Biologische Aktivität
Btk; Antibiotic[1]
Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse bone marrow-derived mast cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:Pretreated for 30 min
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Result:Inhibited both the basal and activation levels of Btk autophosphorylating activity in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:0, 0.15, 1.5, and 15 mg/kg
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Administration:Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
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Result:The early response, as examined 1 hr after antigen challenge, was not affected by TA.
In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.
Chemical Information
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CAS. Nr. 121-40-4
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Appearance Solid
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Molecular Weight 154.12
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Formel C7H6O4
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Color White to off-white
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SMILES
O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Reinheit & Dokumentation
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Data Sheet (275 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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