Art. -Nr.: HY-169090

TS-002902

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TS-002902 is a selective small-molecule inhibitor of TUT4 and TUT7 enzymes, with IC₅₀ values of 0.36 nM and 9.6 nM, respectively. TS-002902 induces an antiproliferative effect in FOCAD-deficient cancer cells. TS-002902 is applicable for research on FOCAD-deficient solid tumors (including glioblastoma, non-small cell lung cancer, and pancreatic cancer).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.29%
Formel: C₂₈H₂₅Cl₂N₇O₄
Molecular Weight:594.45

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

TS-002902 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

TS-002902 potently inhibits purified human TUT7 catalytic activity with an IC₅₀ of 9.6 nM^[1].
TS-002902 potently inhibits purified human TUT4 catalytic activity with an IC₅₀ of 0.36 nM^[1].
TS-002902 potently inhibits miR-191 uridylation in FOCAD-deleted NCI-H838 cells with a TC₅₀ of 1.9 nM^[1].
TS-002902 (7 days) potently reduces viability of FOCAD-deleted NCI-H838 cells with a TC₅₀ of 0.52 μM after 7 days of incubation^[1].
TS-002902 (7 days) reduces viability of FOCAD-reconstituted NCI-H838 cells with a TC₅₀ of 3.1 μM after 7 days of incubation^[1].
TS-002902 (7 days) reduces viability of FOCAD-normal A549 cells with a TC₅₀ of 11.7 μM after 7 days of incubation^[1].
TS-002902 (7 days) exerts a significantly greater antiproliferative effect in FOCAD-deleted cancer cell lines than in FOCAD-normal cancer cell lines after 7 days of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

FOCAD-deleted NCI-H838 non-small cell lung cancer cells
Concentration:

Multiple concentrations (dose-response curve)
Incubation Time:

7 days
Result:

Potently reduced cell viability with a TC₅₀ of 0.52 μM.

Cell Viability Assay^[1]

Cell Line:

FOCAD-reconstituted NCI-H838 non-small cell lung cancer cells
Concentration:

Multiple concentrations (dose-response curve)
Incubation Time:

7 days
Result:

Reduced cell viability with a TC₅₀ of 3.1 μM.

Cell Viability Assay^[1]

Cell Line:

FOCAD-normal A549 non-small cell lung cancer cells
Concentration:

Multiple concentrations (dose-response curve)
Incubation Time:

7 days
Result:

Reduced cell viability with a TC₅₀ of 11.7 μM.

Cell Viability Assay^[1]

Cell Line:

Panel of 60 diverse cancer cell lines (stratified by FOCAD copy number status)
Concentration:

Multiple concentrations (dose-response curve)
Incubation Time:

7 days
Result:

Exerted a significantly higher antiproliferative effect in FOCAD-deleted cell lines compared to FOCAD-normal cell lines.

Chemical Information

Appearance Solid
Molecular Weight 594.45
Formel C₂₈H₂₅Cl₂N₇O₄
Color Light yellow to yellow
SMILES

CN(C1=NC=C(C=C1)N2C=C(C(C3=CC(Cl)=C(C=C32)N4CCC[C@@H]4COC5=C(C6=C(NC=N6)C=N5)Cl)=O)C(O)=O)C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (168.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6822 mL

8.4111 mL

16.8223 mL

5 mM

0.3364 mL

1.6822 mL

3.3645 mL

10 mM

0.1682 mL

0.8411 mL

1.6822 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (8.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (8.41 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Triboulet R, et al. Targeting the Synthetic Lethal Relationship between FOCAD and TUT7 Represents a Potential Therapeutic Opportunity for TUT4/7 Small-Molecule Inhibitors in Cancer. Mol Cancer Ther. 2024;23(12):1779-1788. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6822 mL	8.4111 mL	16.8223 mL	42.0557 mL
	5 mM	0.3364 mL	1.6822 mL	3.3645 mL	8.4111 mL
	10 mM	0.1682 mL	0.8411 mL	1.6822 mL	4.2056 mL
	15 mM	0.1121 mL	0.5607 mL	1.1215 mL	2.8037 mL
	20 mM	0.0841 mL	0.4206 mL	0.8411 mL	2.1028 mL
	25 mM	0.0673 mL	0.3364 mL	0.6729 mL	1.6822 mL
	30 mM	0.0561 mL	0.2804 mL	0.5607 mL	1.4019 mL
	40 mM	0.0421 mL	0.2103 mL	0.4206 mL	1.0514 mL
	50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8411 mL
	60 mM	0.0280 mL	0.1402 mL	0.2804 mL	0.7009 mL
	80 mM	0.0210 mL	0.1051 mL	0.2103 mL	0.5257 mL
	100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.4206 mL

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TS-002902

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

TS-002902

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

TS-002902 Related Classifications

HY-169090 Related Classifications