TSI-01
Based on 1 Customer Validation
TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s=0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). 60 μM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.52%
- CAS. Nr.: 704878-75-1
- Formel: C14H11Cl2NO4
- Molecular Weight:328.15
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Cysteine Targeted Covalent Library
HY-L153
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Highly Selective Inhibitors Library
HY-L158
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Macrophage Related Compound Library
HY-L174
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Biologische Aktivität
Chemical Information
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CAS. Nr. 704878-75-1
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Appearance Solid
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Molecular Weight 328.15
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Formel C14H11Cl2NO4
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Color White to off-white
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SMILES
O=C(C1=CC=C(N2C(C(Cl)=C(C2=O)Cl)=O)C=C1)OC(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (380.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0474 mL | 15.2369 mL | 30.4739 mL | 76.1847 mL |
| 5 mM | 0.6095 mL | 3.0474 mL | 6.0948 mL | 15.2369 mL | |
| 10 mM | 0.3047 mL | 1.5237 mL | 3.0474 mL | 7.6185 mL | |
| 15 mM | 0.2032 mL | 1.0158 mL | 2.0316 mL | 5.0790 mL | |
| 20 mM | 0.1524 mL | 0.7618 mL | 1.5237 mL | 3.8092 mL | |
| 25 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0474 mL | |
| 30 mM | 0.1016 mL | 0.5079 mL | 1.0158 mL | 2.5395 mL | |
| 40 mM | 0.0762 mL | 0.3809 mL | 0.7618 mL | 1.9046 mL | |
| 50 mM | 0.0609 mL | 0.3047 mL | 0.6095 mL | 1.5237 mL | |
| 60 mM | 0.0508 mL | 0.2539 mL | 0.5079 mL | 1.2697 mL | |
| 80 mM | 0.0381 mL | 0.1905 mL | 0.3809 mL | 0.9523 mL | |
| 100 mM | 0.0305 mL | 0.1524 mL | 0.3047 mL | 0.7618 mL |
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