Art. -Nr.: HY-120920

UNC9995

1 Cited Publications

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UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.

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Reinheit: 99.93%
CAS. Nr.: 1354030-52-6
Formel: C₂₀H₂₁Cl₂N₃OS
Molecular Weight:422.37

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

UNC9995 Chemical Structure

CAS. Nr.: 1354030-52-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

D₂ Receptor

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

UNC9995 (10 μM; 1 h) promotes the combination of STAT3 and β-arrestin2, induced by IL-6 (300 ng/mL; 24 h) in primary astrocytes. And it also inhibits activation of STING, TBK1, JAK^[1].
UNC9995 (1, 5, 10, and 20 μM; 1 h) abolishes the apoptosis and inflammation of both WT and Arrb2^−/− astrocytes stimulated with IL-6 (300 ng/mL) for 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Primary astrocytes
Concentration:

10 μM
Incubation Time:

1 h for pre-incubation; with 300 ng/mL IL-6
Result:

Enhanced the interaction between STAT3 and β-arrestin2.
Abolished the activation of cGAS-STING and JAK/STAT3 pathway stimulated by IL-6, decreased the level of p-STING, p-TBK1, p-JAK.

In Vivo

UNC9995 (2 mg/kg/day, i.p, 2 weeks) ameliorates depressive-like behavioral phenotype and improves the loss of astrocytes in the hippocampus in both Chronic social defeated stress (CSDS) model and Chronic unpredictable mild stress (CUMS) model in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Chronic unpredictable mild stress (CUMS) mouse model^[1]
Dosage:

2 mg/kg/d
Administration:

IP; 2 weeks
Result:

Improved depressive-like symptoms of CUMS mouse model in WT mice but not Arrb2^−/− mice.

Chemical Information

CAS. Nr. 1354030-52-6
Appearance Solid
Molecular Weight 422.37
Formel C₂₀H₂₁Cl₂N₃OS
Color White to off-white
SMILES

ClC1=CC=CC(N2CCN(CC2)CCCOC3=CC4=C(C=C3)SC=N4)=C1Cl
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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SSRN

2026 Apr 14.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (118.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3676 mL

11.8380 mL

23.6759 mL

5 mM

0.4735 mL

2.3676 mL

4.7352 mL

10 mM

0.2368 mL

1.1838 mL

2.3676 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (2.96 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu Y, et al. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. J Neuroinflammation. 2022 Oct 1;19(1):240. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3676 mL	11.8380 mL	23.6759 mL	59.1898 mL
	5 mM	0.4735 mL	2.3676 mL	4.7352 mL	11.8380 mL
	10 mM	0.2368 mL	1.1838 mL	2.3676 mL	5.9190 mL
	15 mM	0.1578 mL	0.7892 mL	1.5784 mL	3.9460 mL
	20 mM	0.1184 mL	0.5919 mL	1.1838 mL	2.9595 mL
	25 mM	0.0947 mL	0.4735 mL	0.9470 mL	2.3676 mL
	30 mM	0.0789 mL	0.3946 mL	0.7892 mL	1.9730 mL
	40 mM	0.0592 mL	0.2959 mL	0.5919 mL	1.4797 mL
	50 mM	0.0474 mL	0.2368 mL	0.4735 mL	1.1838 mL
	60 mM	0.0395 mL	0.1973 mL	0.3946 mL	0.9865 mL
	80 mM	0.0296 mL	0.1480 mL	0.2959 mL	0.7399 mL
	100 mM	0.0237 mL	0.1184 mL	0.2368 mL	0.5919 mL

Keywords

UNC9995

1 Cited Publications

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UNC9995

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Neuronal Signaling Compound Library

Neurotransmitter Receptor Compound Library

Anti-Parkinson's Disease Compound Library

Antidepressant Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Dopamine Receptor Compound Library

Inflammasomes related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) UNC9995

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

UNC9995

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Neuronal Signaling Compound Library

Neurotransmitter Receptor Compound Library

Anti-Parkinson's Disease Compound Library

Antidepressant Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Dopamine Receptor Compound Library

Inflammasomes related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) UNC9995

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

UNC9995 Related Classifications

HY-120920 Related Classifications