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Art. -Nr.: HY-N15384

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Wrightiadione

Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC₅₀ values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways.

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CAS. Nr.: 148180-61-4
Formel: C₁₆H₈O₃
Molecular Weight:248.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Wrightiadione Chemical Structure

CAS. Nr.: 148180-61-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

TrkA

55.8 μM (IC₅₀)

PLK3

9 μM (IC₅₀)

Alle Trk Receptor Isoform-spezifische Produkte anzeigen :

Alle Polo-like Kinase (PLK) Isoform-spezifische Produkte anzeigen :

In Vitro

Wrightiadione (compound 1) at 10 μM selectively inhibits TrkA and PLK3 against a kinome panel consisting of 97 cancer-related kinases in a high-throughput binding assay^[1].
Wrightiadione inhibits the activity of purified TrkA kinase in radiokinase assays, with an IC₅₀ value of 55.8 μM^[1].
Wrightiadione inhibits the kinase activity of purified PLK3 in radiometric kinase assays, with an IC₅₀ of 9.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 148180-61-4
Molecular Weight 248.24
Formel C₁₆H₈O₃
SMILES

O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
Structure Classification
- Flavonoids
- Isoflavones
- Flavonoids
- Other Flavonoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jeong Y, et al. Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors. Bioorganic & medicinal chemistry letters. 2015 Nov 15;25(22):5186-9.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Wrightiadione

Alle Trk Receptor Isoform-spezifische Produkte anzeigen

Alle Polo-like Kinase (PLK) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Wrightiadione Related Classifications

HY-N15384 Related Classifications

Bioz

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