Zuclomiphene
Based on 1 publication(s) in Google Scholar
Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease.
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- CAS. Nr.: 15690-55-8
- Formel: C26H28ClNO
- Molecular Weight:405.96
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Publications Citing Use of MedChemExpress (MCE) Zuclomiphene
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| HT-1080 | IC50 |
37.86 μM
Compound: 76
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Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
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[PMID: 29847930] |
Zuclomiphene (30 mg/kg, i.p., twice a week) reduces cholesterol content in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice[1]
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Dosage:4 and 40 mg/kg
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Administration:Orally gavage
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Result:Reduced leydig cells surrounding the tubules in size and numbers.
Showed testicular degeneration and an absence of sperm in the seminiferous tubules.
Reduced kidney weights and body weight.
Reduced levels of LH, FSH and testosterone.
Chemical Information
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CAS. Nr. 15690-55-8
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Molecular Weight 405.96
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Formel C26H28ClNO
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SMILES
Cl/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(CC)CC)C=C2)/C3=CC=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Biol Chem
TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice. [Abstract]2024 Oct 23:107929. PMID: 39454957
Reinheit & Dokumentation
Verweise
[1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50. [Content Brief]
[2]. Ramsey RB, et al. Effects of zuclomiphene in combination with triparanol and ay-9944 on developing rat CNS morphology and biochemistry. Acta Neuropathol. 1977 Jul 15;39(1):97-100. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zuclomiphene Related Classifications
HY-B1617 Related Classifications
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