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Cat. No.: HY-108331R

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3-TYP (Standard)

3-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC₅₀of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

For research use only. We do not sell to patients.

CAS No.: 120241-79-4
Formula: C₇H₆N₄
Molecular Weight:146.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-TYP (Standard) Chemical Structure

CAS No.: 120241-79-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Targets: Sirtuin (SIRT) 3, Methionine Adenosyltransferase (MAT) 2, Indoleamine 2,3-Dioxygenase (IDO)^[3]
IC50: ~38 μM (SIRT3)^[3]

All Sirtuin Isoforms :

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Chemical Information

CAS No. 120241-79-4
Molecular Weight 146.15
Formula C₇H₆N₄
SMILES

C1(C2=CN=NN2)=CC=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51. [Content Brief]

[2]. Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63(2). [Content Brief]

[3]. Galli U, et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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3-TYP (Standard)

All Sirtuin Isoforms

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

3-TYP (Standard) Related Classifications

HY-108331R Related Classifications