SSZ
Based on 1 publication(s) in Google Scholar
SSZ is a multi-target inhibitor, which targets multiple pathological mechanisms of Alzheimer's disease (AD). SSZ targets acetylcholinesterase, butyrylcholinesterase, β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and γ-secretase. SSZ ameliorates Alzheimer’s diseases and exhibits neuroprotective effect in mice.
For research use only. We do not sell to patients.
- Purity: 98.13%
- CAS No.: 1262287-23-9
- Formula: C18H19ClN4
- Molecular Weight:326.82
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Multi-Target Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Drug Repurposing Compound Library Plus
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Clinical Compound Library
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Anti-Aging Compound Library
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Drug Repurposing Compound Library
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Publications Citing Use of MedChemExpress (MCE) SSZ
More
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1262287-23-9
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Appearance Solid
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Molecular Weight 326.82
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Formula C18H19ClN4
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Color Off-white to light yellow
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SMILES
ClC1=CC(C2=CNC3=C2C=CC=N3)=CC(NC4CCCCC4)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Immunol
Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels. [Abstract]2025 Jun 27;10(108):eadn1630. PMID: 40577443
Solvent & Solubility
DMSO : 50 mg/mL (152.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0598 mL | 15.2989 mL | 30.5979 mL | 76.4947 mL |
| 5 mM | 0.6120 mL | 3.0598 mL | 6.1196 mL | 15.2989 mL | |
| 10 mM | 0.3060 mL | 1.5299 mL | 3.0598 mL | 7.6495 mL | |
| 15 mM | 0.2040 mL | 1.0199 mL | 2.0399 mL | 5.0996 mL | |
| 20 mM | 0.1530 mL | 0.7649 mL | 1.5299 mL | 3.8247 mL | |
| 25 mM | 0.1224 mL | 0.6120 mL | 1.2239 mL | 3.0598 mL | |
| 30 mM | 0.1020 mL | 0.5100 mL | 1.0199 mL | 2.5498 mL | |
| 40 mM | 0.0765 mL | 0.3825 mL | 0.7649 mL | 1.9124 mL | |
| 50 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5299 mL | |
| 60 mM | 0.0510 mL | 0.2550 mL | 0.5100 mL | 1.2749 mL | |
| 80 mM | 0.0382 mL | 0.1912 mL | 0.3825 mL | 0.9562 mL | |
| 100 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7649 mL |
SSZ Related Classifications
HY-163885 Related Classifications
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