Sucralose
Based on 3 publication(s) in Google Scholar
Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 56038-13-2
- Formula: C12H19Cl3O8
- Molecular Weight:397.63
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Sucralose
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 56038-13-2
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Appearance Solid
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Molecular Weight 397.63
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Formula C12H19Cl3O8
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Color White to off-white
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SMILES
ClC[C@]1(O[C@H](CCl)[C@@H](O)[C@@H]1O)O[C@H]([C@@H]([C@@H](O)[C@H]2Cl)O)O[C@@H]2CO
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Synonyms
E955; Trichlorosucrose
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Cancer Immunol Res
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. [Abstract]2022 Dec 2;10(12):1542-1558. PMID: 36255412 -
NPJ Sci Food
2026 Mar 24. PMID: 41876529 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
H2O : 100 mg/mL (251.49 mM; Need ultrasonic)
DMSO : 100 mg/mL (251.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (125.75 mM); Clear solution; Need ultrasonic
Protocol
Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17. [Content Brief]
[2]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5149 mL | 12.5745 mL | 25.1490 mL | 62.8725 mL |
| 5 mM | 0.5030 mL | 2.5149 mL | 5.0298 mL | 12.5745 mL | |
| 10 mM | 0.2515 mL | 1.2575 mL | 2.5149 mL | 6.2873 mL | |
| 15 mM | 0.1677 mL | 0.8383 mL | 1.6766 mL | 4.1915 mL | |
| 20 mM | 0.1257 mL | 0.6287 mL | 1.2575 mL | 3.1436 mL | |
| 25 mM | 0.1006 mL | 0.5030 mL | 1.0060 mL | 2.5149 mL | |
| 30 mM | 0.0838 mL | 0.4192 mL | 0.8383 mL | 2.0958 mL | |
| 40 mM | 0.0629 mL | 0.3144 mL | 0.6287 mL | 1.5718 mL | |
| 50 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2575 mL | |
| 60 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0479 mL | |
| 80 mM | 0.0314 mL | 0.1572 mL | 0.3144 mL | 0.7859 mL | |
| 100 mM | 0.0251 mL | 0.1257 mL | 0.2515 mL | 0.6287 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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