Anticancer agent 76
Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2448091-11-8
- Formula: C32H33NO5S
- Molecular Weight:543.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
41.63 μM
Compound: CT2-3
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Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 32044229] |
| NCI-H460 | IC50 |
38.03 μM
Compound: CT2-3
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Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 32044229] |
Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and H460
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Concentration:0, 10, 20, 40, 60 and 80 μM
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Incubation Time:24 h
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Result:Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively.
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Cell Line:H460
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Concentration:40 μM
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Incubation Time:24 h
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Result:Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1.
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Cell Line:A549 and H460
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Concentration:20 μM and 40 μM
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Incubation Time:24 h
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Result:Induced apoptosis.
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Cell Line:H460 cell
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Concentration:40 μM
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Incubation Time:24 h
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Result:Down-regulated mRNA of TOP2B, TOP3B and c-Myc.
Chemical Information
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CAS No. 2448091-11-8
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Molecular Weight 543.67
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Formula C32H33NO5S
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SMILES
O=C1N(CCCCS(CCOC2=CC=C(CC=C)C=C2C3=CC(CC=C)=CC=C3O)=O)C(C4=C1C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 76 Related Classifications
HY-150571 Related Classifications
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