UNC11676A
UNC11676A is an MDA5 ATPase inhibitor with IC50 values of 6 μM, 115 μM and 108 μM against MDA5, LGP2 and DDX1, respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 3126213-85-9
- Formula: C23H17F3N4O4S2
- Molecular Weight:534.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Helicase |
UNC11676A potently and selectively inhibits truncated human MDA5ΔCARD ATPase activity (IC50 = 6 μM), with 18-fold lower potency against full-length human LGP2 (IC50 = 115 μM) and full-length human DDX1 (IC50 = 108 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3126213-85-9
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Molecular Weight 534.53
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Formula C23H17F3N4O4S2
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SMILES
O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=C(C(F)(F)F)C=CC=C4)=O)S3)=CS2)C=C1OC)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC11676A Related Classifications
HY-185893 Related Classifications
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