BET-IN-23

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
A549	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
CWR22R	IC₅₀	2.45 μM Compound: 23	Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
DU-145	IC₅₀	5.48 μM Compound: 23	Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
HepG2	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
LNCaP	IC₅₀	0.25 μM Compound: 23	Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MDA-MB-231	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MOLM-13	IC₅₀	0.061 μM Compound: 23	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MV4-11	IC₅₀	0.014 μM Compound: 23	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
NCI-H1975	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
NCI-H2122	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]

Cell Line

Type

Value

Description

References

A549

IC₅₀

>6 μM

Compound: 23

Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

CWR22R

IC₅₀

2.45 μM

Compound: 23

Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

DU-145

IC₅₀

5.48 μM

Compound: 23

Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

HepG2

IC₅₀

>6 μM

Compound: 23

Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

LNCaP

IC₅₀

0.25 μM

Compound: 23

Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

MDA-MB-231

IC₅₀

>6 μM

Compound: 23

Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

MOLM-13

IC₅₀

0.061 μM

Compound: 23

Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

MV4-11

IC₅₀

0.014 μM

Compound: 23

Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

NCI-H1975

IC₅₀

>6 μM

Compound: 23

Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

NCI-H2122

IC₅₀

>6 μM

Compound: 23

Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay

[PMID: 38175809]

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