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製品番号: HY-163160

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BET-IN-23

Bet-in-23 (Compound 23) is a BD2-selective BET inhibitor with an IC₅₀ of 2.9 nM. BET-IN-23 has anticancer activity and can significantly inhibit the proliferation of acute myeloid leukemia (AML) cell lines by inducing G0/G1 arrest and apoptosis in vitro.

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CAS 番号: 2953287-57-3
分子式: C₂₉H₃₄FN₃O₅
分子量:523.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BET-IN-23 構造式

CAS 番号: 2953287-57-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 2.9 nM (BET)^[1].

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
CWR22R	IC₅₀	2.45 μM Compound: 23	Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
DU-145	IC₅₀	5.48 μM Compound: 23	Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
HepG2	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
LNCaP	IC₅₀	0.25 μM Compound: 23	Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MDA-MB-231	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MOLM-13	IC₅₀	0.061 μM Compound: 23	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
MV4-11	IC₅₀	0.014 μM Compound: 23	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
NCI-H1975	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]
NCI-H2122	IC₅₀	>6 μM Compound: 23	Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay	[PMID: 38175809]

化学情報

CAS 番号 2953287-57-3
分子量 523.60
分子式 C₂₉H₃₄FN₃O₅
SMILES

CN1C=C(C(NCC(N2CCOCC2)=O)=CC1=O)C3=C(C=CC(C(C)(O)C)=C3)OC4=C(C=C(C=C4C)F)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jiang W, et al. Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J Med Chem. 2024 Jan 4. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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BET-IN-23

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

BET-IN-23 関連分類

HY-163160 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target