2. Apoptosis Epigenetics
  3. Epigenetic Reader Domain Apoptosis
  4. BET-IN-23

Bet-in-23 (Compound 23) is a BD2-selective BET inhibitor with an IC50 of 2.9 nM. BET-IN-23 has anticancer activity and can significantly inhibit the proliferation of acute myeloid leukemia (AML) cell lines by inducing G0/G1 arrest and apoptosis in vitro.

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BET-IN-23

BET-IN-23 Chemical Structure

CAS No. : 2953287-57-3

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BET-IN-23 Related Antibodies

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Description

Bet-in-23 (Compound 23) is a BD2-selective BET inhibitor with an IC50 of 2.9 nM. BET-IN-23 has anticancer activity and can significantly inhibit the proliferation of acute myeloid leukemia (AML) cell lines by inducing G0/G1 arrest and apoptosis in vitro[1].

IC50 & Target

IC50: 2.9 nM (BET)[1].
Cellular Effect
Cell Line Type Value Description References
A549 IC50
>6 μM
Compound: 23
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
CWR22R IC50
2.45 μM
Compound: 23
Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human 22Rv1 cells expressing androgen receptor V7 variant assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
DU-145 IC50
5.48 μM
Compound: 23
Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against AR-negative human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
HepG2 IC50
>6 μM
Compound: 23
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
LNCaP IC50
0.25 μM
Compound: 23
Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against AR-positive human LNCaP cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
MDA-MB-231 IC50
>6 μM
Compound: 23
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
MOLM-13 IC50
0.061 μM
Compound: 23
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
MV4-11 IC50
0.014 μM
Compound: 23
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
NCI-H1975 IC50
>6 μM
Compound: 23
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
NCI-H2122 IC50
>6 μM
Compound: 23
Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
Antiproliferative activity against human NCI-H2122 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
[PMID: 38175809]
Molecular Weight

523.60

Formula

C29H34FN3O5
CAS No.
SMILES

CN1C=C(C(NCC(N2CCOCC2)=O)=CC1=O)C3=C(C=CC(C(C)(O)C)=C3)OC4=C(C=C(C=C4C)F)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BET-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-232953287-57-3Epigenetic Reader DomainApoptosisLeukemiaMV;411 mouseTumourBETInhibitorinhibitorinhibit

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BET-IN-23
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HY-163160
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