BRD4 Inhibitor-34

Cat. No.: HY-W192171 Purity: 96.84%: Data Sheet
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BRD4 Inhibitor-34 (Compound 12a) is a BRD4 inhibitor with an IC₅₀ of 24 μM.

For research use only. We do not sell to patients.

BRD4 Inhibitor-34 Chemical Structure

CAS No. : 1095051-68-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Epigenetic Reader Domain Isoform Specific Products:

View All Isoforms

Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

Biological Activity
Purity & Documentation
References
Customer Review

Description

BRD4 Inhibitor-34 (Compound 12a) is a BRD4 inhibitor with an IC₅₀ of 24 μM^[1].

IC₅₀ & Target

IC50: 24 μM (BRD4)^[1].

Molecular Weight

211.67

Formula

C₉H₆ClNOS

CAS No.

1095051-68-5

Appearance

Solid

SMILES

O=C1SC=C(C2=CC=CC(Cl)=C2)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 150 mg/mL (708.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7243 mL	23.6217 mL	47.2434 mL
5 mM	0.9449 mL	4.7243 mL	9.4487 mL
10 mM	0.4724 mL	2.3622 mL	4.7243 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.84%

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COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Zhao L, et al. Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain. J Med Chem. 2013;56(10):3833-3851. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7243 mL	23.6217 mL	47.2434 mL	118.1084 mL
	5 mM	0.9449 mL	4.7243 mL	9.4487 mL	23.6217 mL
	10 mM	0.4724 mL	2.3622 mL	4.7243 mL	11.8108 mL
	15 mM	0.3150 mL	1.5748 mL	3.1496 mL	7.8739 mL
	20 mM	0.2362 mL	1.1811 mL	2.3622 mL	5.9054 mL
	25 mM	0.1890 mL	0.9449 mL	1.8897 mL	4.7243 mL
	30 mM	0.1575 mL	0.7874 mL	1.5748 mL	3.9369 mL
	40 mM	0.1181 mL	0.5905 mL	1.1811 mL	2.9527 mL
	50 mM	0.0945 mL	0.4724 mL	0.9449 mL	2.3622 mL
	60 mM	0.0787 mL	0.3937 mL	0.7874 mL	1.9685 mL
	80 mM	0.0591 mL	0.2953 mL	0.5905 mL	1.4764 mL
	100 mM	0.0472 mL	0.2362 mL	0.4724 mL	1.1811 mL