Bromoxynil octanoate
Based on 1 publication(s) in Google Scholar
Bromoxynil octanoate is an orally active Herbicide and Cx43 gap junction channel inhibitor. Bromoxynil octanoate activates ERK1/2 and NF-κB-P65. Bromoxynil octanoate induces Apoptosis. Bromoxynil octanoate induces oxidative stress and inflammation. Bromoxynil octanoate causes reproductive toxicity by reducing epididymal sperm count and motility as well as serum testosterone levels.
For research use only. We do not sell to patients.
- Purity : 99.28%
- CAS No.: 1689-99-2
- Formula: C15H17Br2NO2
- Molecular Weight:403.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bromoxynil octanoate
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Biological Activity
Description
IC50 & Target
[1]|
ERK1 |
ERK2 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male albino; 160-180 g; 12-16 weeks old)[3]
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Dosage:40 mg/kg
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Administration:p.o.; once daily; 28 days
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Result:Sperm count decreased to 1.79 ×10^6/mL, a 73.12% decrease versus control.
Sperm viability decreased to 30.09%, a 57.03% decrease versus control.
Serum testosterone decreased to 1.75 ng/mL, a 55.85% decrease versus control.
MDA content increased 4.6-fold versus control.
NO content increased 1.79-fold versus control.
SOD activity decreased 56.14% versus control.
CAT activity decreased 70.68% versus control.
GPx activity decreased 76.34% versus control.
PPAR-γ content decreased 81.89%, Nrf-2 content decreased 67.07%, and HO-1 content decreased 66.53% versus control.
TNF-α content increased 3.42-fold and IL-1β content increased 1.7-fold versus control.
Caspase-3 content increased 2.57-fold and Bcl-2 content increased 76.37% versus control.
Gene expression: PPAR-γ downregulated 73.33%, Nrf-2 downregulated 208.82%, HO-1 downregulated 83.18%, NF-κB upregulated 658.82%, IL-10 downregulated 82.73%, FOXO1 upregulated 197.27%, Caspase-3 upregulated 272.64, BAX upregulated 178.9, and Bcl-2 downregulated 87.38% versus control.
Histopathological scoring: disturbed histological architecture 4, tubular degeneration/atrophy 4, widening of interstitial tissue 4, and dilated congested blood vessels 4.
Chemical Information
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CAS No. 1689-99-2
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Appearance Solid
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Molecular Weight 403.11
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Formula C15H17Br2NO2
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Color White to off-white
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SMILES
CCCCCCCC(OC1=C(Br)C=C(C#N)C=C1Br)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (248.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4807 mL | 12.4036 mL | 24.8071 mL | 62.0178 mL |
| 5 mM | 0.4961 mL | 2.4807 mL | 4.9614 mL | 12.4036 mL | |
| 10 mM | 0.2481 mL | 1.2404 mL | 2.4807 mL | 6.2018 mL | |
| 15 mM | 0.1654 mL | 0.8269 mL | 1.6538 mL | 4.1345 mL | |
| 20 mM | 0.1240 mL | 0.6202 mL | 1.2404 mL | 3.1009 mL | |
| 25 mM | 0.0992 mL | 0.4961 mL | 0.9923 mL | 2.4807 mL | |
| 30 mM | 0.0827 mL | 0.4135 mL | 0.8269 mL | 2.0673 mL | |
| 40 mM | 0.0620 mL | 0.3101 mL | 0.6202 mL | 1.5504 mL | |
| 50 mM | 0.0496 mL | 0.2481 mL | 0.4961 mL | 1.2404 mL | |
| 60 mM | 0.0413 mL | 0.2067 mL | 0.4135 mL | 1.0336 mL | |
| 80 mM | 0.0310 mL | 0.1550 mL | 0.3101 mL | 0.7752 mL | |
| 100 mM | 0.0248 mL | 0.1240 mL | 0.2481 mL | 0.6202 mL |
Bromoxynil octanoate Related Classifications
HY-136370 Related Classifications
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Keywords
- Bromoxynil octanoate
- 1689-99-2
- Herbicide
- Gap Junction Protein
- ERK
- NF-κB
- Apoptosis
- Extracellular signal regulated kinases
- Nuclear factor-κB
- Nuclear factor-kappaB
- Cx43 gap junction channel
- ERK1/2 phosphorylation
- IAR20 rat liver epithelial cells
- NF-κB-P65-mediated inflammatory signaling
- Sprague Dawley rats
- apoptosis
- inflammation
- oxidative stress
- reproductive toxicity
- testicular toxicity
- Inhibitor
- inhibitor
- inhibit