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Cat. No.: HY-190595

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C129-0055

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research.

For research use only. We do not sell to patients.

CAS No.: 442897-27-0
Formula: C₂₅H₂₇N₃O
Molecular Weight:385.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

C129-0055 Chemical Structure

CAS No.: 442897-27-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
- In Vitro
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Biological Activity

Description

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

All TRP Channel Isoforms :

In Vitro

C129-0055 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium flux in HEK293-TRPV1 cells, with an FDSS IC₅₀ of 9.74 μM^[1].
C129-0055 (0.12-10 μM) inhibits Capsaicin-induced TRPV1 currents in HEK293-TRPV1 cells in a concentration-dependent manner, with a patch-clamp IC₅₀ of 0.95 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 442897-27-0
Molecular Weight 385.50
Formula C₂₅H₂₇N₃O
SMILES

CC1=CC(N2CCCCC2)=NC3=C1C=C(NC(/C=C/C4=CC=C(C)C=C4)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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C129-0055

All TRP Channel Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

C129-0055 Related Classifications

HY-190595 Related Classifications

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