Dipivefrin
Dipivefrin is an α/β-adrenoceptor agonist and a prodrug of epinephrine. Dipivefrin regulates intraocular pressure by agonizing α/β-adrenoceptors and modulating the aqueous humor outflow pathway. Dipivefrin acts on neuroblastoma cells and downregulates glutamate-induced intracellular calcium levels. Dipivefrin is used in research related to α/β-adrenoceptor-mediated diseases, such as glaucoma.
For research use only. We do not sell to patients.
- CAS No.: 52365-63-6
- Formula: C19H29NO5
- Molecular Weight:351.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
α adrenergic receptor |
β adrenergic receptor |
In Vitro
Dipivefrin (2.8-280 μM; 100 min) significantly inhibits the proliferation of cultured human corneal stromal cells only at a high concentration of 280 μM[3].
Dipivefrin (0.28-28 mM; 100 seconds) dose-dependently inhibits glutamate-induced elevation of [Ca2+]i and decreases basal [Ca2+]i in cultured N1E-115 neuroblastoma cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dipivefrin (10 µg/kg; i.p.; before memory retrieval) administered before memory retrieval enhances the ability of alcohol-associated light cues to serve as conditioned reinforcers, indicating bidirectional modulation of alcohol memory reconsolidation through enhanced central adrenergic signaling[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 52365-63-6
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Molecular Weight 351.44
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Formula C19H29NO5
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SMILES
CC(C)(C(OC1=CC=C(C=C1OC(C(C)(C)C)=O)C(CNC)O)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dipivefrin Related Classifications
HY-121398 Related Classifications
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