Methacholine iodide
Based on 6 publication(s) in Google Scholar
Methacholine iodide is a potent muscarinic-3 (M3) agonist. Methacholine iodide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine iodide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine iodide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
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- CAS No.: 625-19-4
- Formula: C8H18INO2
- Molecular Weight:287.14
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Methacholine iodide
More- Cell Death Dis. 2025 Oct 7;16(1):716. [Abstract]
- J Ethnopharmacol. 2026 Mar 25:359:121125. [Abstract]
- J Ethnopharmacol. 2026 Feb 10:356:120782. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Nov 12. [Abstract]
- Immunobiology. 2025 Jul 16;230(4):153103. [Abstract]
- Aging (Albany NY). 2021 Sep 13;13(17):21729-21742. [Abstract]
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Chemical Information
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CAS No. 625-19-4
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Molecular Weight 287.14
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Formula C8H18INO2
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SMILES
O=C(C)OC(C[N+](C)(C)C)C.[I-]
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Synonyms
Acetyl-β-methylcholine iodide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
E3 Ubiquitin ligases Cbl-b and c-Cbl maintain the homeostasis of macrophages by regulating the M-CSF/M-CSFR signaling axis. [Abstract]2025 Oct 7;16(1):716. PMID: 41057360
Methacholine iodide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Oct 7;16(1):716. [Abstract]
Methacholine chloride (6.25-50 mg/mL; i.n.; 5 min). The breathing frequency (f), inspiratory time (Ti), expiratory time (Te), tidal volume, baseline (TVb), and expiratory end pressure (EEP) of dKO mice were measured by the WBP system.
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J Ethnopharmacol
YiQi GuBen formula targets EHMT2 and enhances NEDD4L transcription to combat epithelial-mesenchymal transition and airway remodeling in asthma. [Abstract]2026 Mar 25:359:121125. PMID: 41475628
Methacholine iodide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2026 Mar 25:359:121125. [Abstract]
AHR of OVA-sensitized BALB/c mice with or without YQGBF treatment was examined via Methacholine chloride (10-30 mg/mL; 3 min) exposure.
Methacholine iodide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2026 Mar 25:359:121125. [Abstract]
AHR of OVA-sensitized BALB/c mice with or without EHMT2 overexpression was examined via Methacholine chloride (10–30 mg/mL; 3 min) exposure.
Methacholine iodide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2026 Mar 25:359:121125. [Abstract]
AHR of OVA-sensitized BALB/c mice with EHMT2 overexpression and NEDD4L overexpression was examined via Methacholine chloride (10–30 mg/mL; 3 min) exposure.
Methacholine iodide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2026 Mar 25:359:121125. [Abstract]
AHR of OVA-sensitized BALB/c mice with EHMT2 overexpression and treated with Wnt/β-catenin inhibitor ICG-001 was examined via Methacholine chloride (10–30 mg/mL; 3 min) exposure.
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J Ethnopharmacol
Network pharmacology and experimental validation identify the targets of Marsdenia tenacissima in neutrophilic asthma treatment. [Abstract]2026 Feb 10:356:120782. PMID: 41135618 -
Naunyn Schmiedebergs Arch Pharmacol
Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma. [Abstract]2025 Nov 12. PMID: 41222693 -
Immunobiology
Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma. [Abstract]2025 Jul 16;230(4):153103. PMID: 40695068 -
Aging (Albany NY)
2021 Sep 13;13(17):21729-21742. PMID: 34516405
Purity & Documentation
References
[1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176. [Content Brief]
[2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23. [Content Brief]
[3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680. [Content Brief]
[4]. Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84. [Content Brief]
[5]. Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8. [Content Brief]
[6]. Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46(1-2):23-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methacholine iodide Related Classifications
HY-A0083C Related Classifications
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