Cat. No.: HY-N0407

Picroside I

(Synonyms: 6'-Cinnamoylcatalpol)

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Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ.

For research use only. We do not sell to patients.

Purity: 99.31%
CAS No.: 27409-30-9
Formula: C₂₄H₂₈O₁₁
Molecular Weight:492.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Picroside I Chemical Structure

CAS No.: 27409-30-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II^[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ^[2].

IC₅₀ & Target^[2]

STAT6

All STAT Isoforms :

In Vivo

Picroside I (20 mg/kg, o.p, 12 d) reduces AHR in the experimental asthma model and reduces OVA-associated IgE levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ovalbumin (OVA) systematic sensitization BALB/c mice model^[2]
Dosage:

0.2, 2.0 and 20 mg/kg
Administration:

Orally, once daily, from day 20 to day 32
Result:

Inhibited allergen-triggered inflammatory cell infiltration.

Chemical Information

CAS No. 27409-30-9
Appearance Solid
Molecular Weight 492.47
Formula C₂₄H₂₈O₁₁
Color White to off-white
SMILES

OC[C@]12[C@@H](O2)[C@@H](O)[C@@]3([H])[C@]1([H])[C@H](O[C@]4([H])O[C@H](COC(/C=C/C5=CC=CC=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3
Synonyms

6'-Cinnamoylcatalpol
Structure Classification
- Terpenoids
- Iridoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (507.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 116.67 mg/mL (236.91 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0306 mL

10.1529 mL

20.3058 mL

5 mM

0.4061 mL

2.0306 mL

4.0612 mL

10 mM

0.2031 mL

1.0153 mL

2.0306 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 12.5 mg/mL (25.38 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. [Content Brief]

[2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.0306 mL	10.1529 mL	20.3058 mL	50.7645 mL
	5 mM	0.4061 mL	2.0306 mL	4.0612 mL	10.1529 mL
	10 mM	0.2031 mL	1.0153 mL	2.0306 mL	5.0765 mL
	15 mM	0.1354 mL	0.6769 mL	1.3537 mL	3.3843 mL
	20 mM	0.1015 mL	0.5076 mL	1.0153 mL	2.5382 mL
	25 mM	0.0812 mL	0.4061 mL	0.8122 mL	2.0306 mL
	30 mM	0.0677 mL	0.3384 mL	0.6769 mL	1.6922 mL
	40 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2691 mL
	50 mM	0.0406 mL	0.2031 mL	0.4061 mL	1.0153 mL
	60 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8461 mL
	80 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6346 mL
	100 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.5076 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

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Picroside I

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

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Stem Cell Signaling Compound Library

Natural Product Library

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Covalent Screening Library

Differentiation Inducing Compound Library

Glycoside Compound Library

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Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

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MCE Bioactive Compound Library

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Posttranslational Modification Library

Mongolian Medicine Compound Library

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Mass Spectrometry Natural Product Library

All STAT Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Picroside I Related Classifications

HY-N0407 Related Classifications