CD5
CD5 is a lymphocyte surface protein of the scavenger receptor cysteine-rich (SRCR) superfamily, carrying three extracellular SRCR domains on a single transmembrane segment. Expressed on all T cells and on the B-1a subset, CD5 modulates antigen receptor signaling and generally dampens activation; its cytoplasmic tail lacks intrinsic enzymatic motifs but recruits inhibitory regulators. Its best-defined ligand is CD72 on B cells. In clinical immunophenotyping, aberrant strong CD5 expression on mature B cells is a hallmark of chronic lymphocytic leukemia and mantle cell lymphoma, whereas normal mature B cells are negative. CD5 has also been pursued as a target for CAR-T and antibody therapy in T cell malignancies.
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CD5 Recombinant Proteins (15)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
