TWS119 TFA
Based on 34 publication(s) in Google Scholar
TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
For research use only. We do not sell to patients.
- CAS No.: 1507095-58-0
- Formula: C22H16F6N4O6
- Molecular Weight:546.38
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) TWS119 TFA
More- Nat Commun. 2025 Apr 30;16(1):4060. [Abstract]
- Sci Adv. 2023 Sep 29;9(39):eadg8148. [Abstract]
- Research (Wash D C). 2025 Dec 10:8:1030. [Abstract]
- Cell Death Dis. 2025 Nov 3;16(1):786. [Abstract]
- Environ Sci Technol. 2023 Feb 14;57(6):2351-2361. [Abstract]
- Cancer Lett. 2021 Jan 1:496:57-71. [Abstract]
- Cell Commun Signal. 2024 Aug 7;22(1):391. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Jan 20;10(1):5. [Abstract]
- Mol Ther Oncol. 2025 Apr 24;33(2):200986. [Abstract]
- Cell Rep. 2024 May 10;43(5):114226. [Abstract]
- Cancer Cell Int. 2021 Jun 5;21(1):291. [Abstract]
- J Agric Food Chem. 2026 Jul 8;74(26):20662-20673. [Abstract]
- Biochem Pharmacol. 2023 Dec:218:115903. [Abstract]
- Life Sci. 2019 Oct 15:235:116844. [Abstract]
- Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1115-C1127. [Abstract]
- J Lipid Res. 2019 Dec;60(12):2020-2033. [Abstract]
- Prog Neurobiol. 2024 Sep:240:102654. [Abstract]
- FASEB J. 2023 Mar;37(3):e22821. [Abstract]
- Aquacul Rep. 2021, 100774.
- Pathol Res Pract. 2023 Sep:249:154719. [Abstract]
- J Dent Sci. 2024 Jan;19(1):428-437. [Abstract]
- Front Mar Sci. 2021 Jul.
- SLAS Discov. 2024 Nov 5;29(8):100191. [Abstract]
- Neuroscience. 2018 Jul 15:383:129-137. [Abstract]
- Curr Eye Res. 2021 Feb;46(2):159-167. [Abstract]
- bioRxiv. 2026 May 22.
- Sci Total Environ. 2026 Jan 15:1012:181191. [Abstract]
- Patent. US20240325538A1.
- Patent. US20240238271A1.
- Research Square Preprint. 2024 Jan 31.
- Patent. US20230226111A1.
- Oxid Med Cell Longev. 2021 Mar 19:2021:5595376. [Abstract]
- Research Square Preprint. 2020 Dec.
- Patent. US20180263995A1.
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Cell Proliferation/Viability Assay
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Biological Activity
Chemical Information
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CAS No. 1507095-58-0
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Molecular Weight 546.38
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Formula C22H16F6N4O6
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SMILES
OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (34)
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Journal Impact Factor
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Most Recent
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Nat Commun
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression. [Abstract]2025 Apr 30;16(1):4060. PMID: 40307251 -
Sci Adv
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation. [Abstract]2023 Sep 29;9(39):eadg8148. PMID: 37756391 -
Research (Wash D C)
Single-Cell Profiling Identifies Reward Behavior-Related Neurons and Alterations in the Ventral Tegmental Area Based on Arvcf-Knockout Mouse Model. [Abstract]2025 Dec 10:8:1030. PMID: 41395251 -
Cell Death Dis
Atypical cadherin CELSR2 acts as a therapeutic target for glioma through WNT3A/β-catenin signaling. [Abstract]2025 Nov 3;16(1):786. PMID: 41184253 -
Environ Sci Technol
Phosphorus Overload Promotes Hepatic Lipolysis by Suppressing GSK3β-Dependent Phosphorylation of PPARα at Ser84 and Thr265 in a Freshwater Teleost. [Abstract]2023 Feb 14;57(6):2351-2361. PMID: 36728683 -
Cancer Lett
2021 Jan 1:496:57-71. PMID: 33038488 -
Cell Commun Signal
Concomitant targeting of FLT3 and SPHK1 exerts synergistic cytotoxicity in FLT3-ITD+ acute myeloid leukemia by inhibiting β-catenin activity via the PP2A-GSK3β axis. [Abstract]2024 Aug 7;22(1):391. PMID: 39113090 -
NPJ Biofilms Microbiomes
Endogenous Coriobacteriaceae enriched by a high-fat diet promotes colorectal tumorigenesis through the CPT1A-ERK axis. [Abstract]2024 Jan 20;10(1):5. PMID: 38245554
TWS119 TFA purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Jan 20;10(1):5. [Abstract]
Percentage cell proliferation of CT26 cells treated with MEK inhibitor U0126-EtOH (HY-12031; 25 µM), JNK inhibitor SP600125 (HY-12041; 25 µM), P38/MAPK inhibitor SB202190 (HY-10295; 20 µM), GSK3β inhibitor TWS119 (HY-10590; 20 µM), or AR-A014418 (HY-10512; 20 µM), and vehicle or Cori.ST1911. Cell OD was measured using the CCK8 method and normalised to cell proliferation of the control. Inhibitor treatment started 4 h before Cori.ST1911 treatment. Data are represented as mean ± SEM (n = 3 independent tests), analysed by one-way analysis of variance (ANOVA) with Bonferroni’s post-hoc test. n.s., no significance.
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Mol Ther Oncol
Epstein-Barr virus mRNA vaccine synergizes with NK cells to enhance nasopharyngeal carcinoma eradication in humanized mice. [Abstract]2025 Apr 24;33(2):200986. PMID: 40458686 -
Cell Rep
Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus. [Abstract]2024 May 10;43(5):114226. PMID: 38733586 -
Cancer Cell Int
Construction of a prognostic model with histone modification-related genes and identification of potential drugs in pancreatic cancer. [Abstract]2021 Jun 5;21(1):291. PMID: 34090418 -
J Agric Food Chem
Enantioselective Neurotoxicity of Pydiflumetofen in Zebrafish Embryos: R-Enantiomer Disrupts Neurodevelopment via Suppression of Wnt/β-Catenin Signaling. [Abstract]2026 Jul 8;74(26):20662-20673. PMID: 42345402 -
Biochem Pharmacol
Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis. [Abstract]2023 Dec:218:115903. PMID: 37918695 -
Life Sci
XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/β-catenin signaling dependent way. [Abstract]2019 Oct 15:235:116844. PMID: 31499069 -
Am J Physiol Cell Physiol
cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice. [Abstract]2019 Dec 1;317(6):C1115-C1127. PMID: 31509448 -
J Lipid Res
CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway. [Abstract]2019 Dec;60(12):2020-2033. PMID: 31662443 -
Prog Neurobiol
Astrocyte-secreted C3 signaling impairs neuronal development and cognition in autoimmune diseases. [Abstract]2024 Sep:240:102654. PMID: 38945516 -
FASEB J
GSK-3β/β-catenin pathway plays crucial roles in the regulation of NK cell cytotoxicity against myeloma cells. [Abstract]2023 Mar;37(3):e22821. PMID: 36794671
TWS119 TFA purchased from MedChemExpress. Usage Cited in: FASEB J. 2023 Mar;37(3):e22821. [Abstract]
TWS119 substantially increases NF-κB phosphorylation in NK-92 cells.
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Pathol Res Pract
2023 Sep:249:154719. PMID: 37595446 -
J Dent Sci
MiR-34a functions as a tumor suppressor in oral cancer through the inhibition of the Axl/Akt/GSK-3β pathway. [Abstract]2024 Jan;19(1):428-437. PMID: 38303867 -
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SLAS Discov
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ. [Abstract]2024 Nov 5;29(8):100191. PMID: 39510350 -
Neuroscience
Lithium Posttreatment Alleviates Blood-Brain Barrier Injury After Intracerebral Hemorrhage in Rats. [Abstract]2018 Jul 15:383:129-137. PMID: 29775701 -
Curr Eye Res
Human Amniotic Epithelial Cells Promote the Proliferation of Human Corneal Endothelial Cells by Regulating Telomerase Activity via the Wnt/β-catenin Pathway. [Abstract]2021 Feb;46(2):159-167. PMID: 32631162 -
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Sci Total Environ
Activation of the Wnt/β-catenin pathway attenuates the acute toxic effects of copper exposure in Penaeus vannamei. [Abstract]2026 Jan 15:1012:181191. PMID: 41418521 -
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Oxid Med Cell Longev
A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion. [Abstract]2021 Mar 19:2021:5595376. PMID: 33828639 -
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Purity & Documentation
References
[1]. Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14190-6. [Content Brief]
[2]. Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14190-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TWS119 TFA Related Classifications
HY-110074 Related Classifications
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