Uridine 5'-diphosphate
Based on 2 publication(s) in Google Scholar
Uridine-5'-diphosphate (UDP) is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
For research use only. We do not sell to patients.
- CAS No.: 58-98-0
- Formula: C9H14N2O12P2
- Molecular Weight:404.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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- References
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Publications Citing Use of MedChemExpress (MCE) Uridine 5'-diphosphate
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All P2Y Receptor Isoforms
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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P2Y6 Receptor 0.013 μM (EC50) |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| COS-7 | EC50 |
160 μM
Compound: 2, UDP
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Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta
Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta
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[PMID: 25868749] |
| HEK293 | EC50 |
0.16 μM
Compound: 1, UDP
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Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay
Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay
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[PMID: 20446735] |
| HEK293 | EC50 |
160 nM
Compound: 3
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Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production
Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production
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[PMID: 19902968] |
Uridine-5'-diphosphate (100 μM; 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine-5'-diphosphate (100 μM; 3 h) induces chemokine expression in microglia[2].
Uridine-5'-diphosphate (100 μM; 0.5-12 h) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine-5'-diphosphate (10-1000 μM; 3 h) induces activation of NFATc1 and NFATc2 in microglia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary microglia
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Concentration:100 μM
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Incubation Time:For 15 min
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Result:Significantly induced microglial CCL2 and CCL3 mRNA expression.
Chemical Information
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CAS No. 58-98-0
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Molecular Weight 404.16
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Formula C9H14N2O12P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)NC1=O
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Synonyms
UDP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]2025 Oct 17:242:203-219. PMID: 41110517
Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
UDP (Uridine-5'-diphosphate disodium salt) agonism elicited distinct signaling responses, enhancing CaMKII, p-PKC, and SOD2, while suppressing Nrf2 and HO-1, without altering p62, VPS34, LC3B, AMPKα, or mTOR. In contrast, MRS treatment selectively increased HO-1 phosphorylation, while leaving other pathways unaffected.
Uridine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]
Schematic representing the relationship between MRS2578, P2Y6, UDP (Uridine-5'-diphosphate disodium salt), and MRS2693.
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Int Immunopharmacol
Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice. [Abstract]2022 Aug:109:108909. PMID: 35700583
Purity & Documentation
References
[1]. Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43. [Content Brief]
[2]. Pâris A, et al. Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5'-Diphosphate-α-D-glucuronide and Uridine-5'-Diphosphate-α-d-xylose. Carbohydr Res. 2025 Aug;554:109516. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Uridine 5'-diphosphate Related Classifications
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