(2R,4R)-APDC
(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases.
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- CAS No.: 169209-63-6
- Formule: C6H10N2O4
- Masse moléculaire:174.15
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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group II mGlu receptors |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
>100 μM
Compound: 18
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Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
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[PMID: 15801843] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
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Dosage:1 nmol/10 μl; 10 nmol/10μl
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Administration:ICV; daily for 14 days
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Result:Resulted in decreased BrdU-immunoreactive cells in the DG.
Chemical Information
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CAS No. 169209-63-6
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Masse moléculaire 174.15
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Formule C6H10N2O4
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SMILES
O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
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Synonyms
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [Content Brief]
[2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2R,4R)-APDC Related Classifications
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