Cat. No.: HY-N2208

4-Hydroxylonchocarpin

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Based on 2 publication(s) in Google Scholar

4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities.

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Pureté: 98.95%
CAS No.: 56083-03-5
Formule: C₂₀H₁₈O₄
Masse moléculaire:322.36

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

4-Hydroxylonchocarpin Chemical Structure

CAS No.: 56083-03-5

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform p38 MAPK :

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	CC₅₀	2 μM Compound: 19	Cytotoxicity against human HEp-2 cells measured after 3 days by CellTiter 96 aqueous one solution assay (Rvb >100 microM) Cytotoxicity against human HEp-2 cells measured after 3 days by CellTiter 96 aqueous one solution assay (Rvb >100 microM)	[PMID: 38579352]
HEp-2	IC₅₀	>0.8 μM Compound: 19	Antiviral activity against Human respiratory syncytial virus infected in human HEp-2 cells assessed as plaque reduction preincubated with cells 15 mins followed by viral infection for 2.5 hrs and measured after 3 days by crystal violet staining based micr Antiviral activity against Human respiratory syncytial virus infected in human HEp-2 cells assessed as plaque reduction preincubated with cells 15 mins followed by viral infection for 2.5 hrs and measured after 3 days by crystal violet staining based micr	[PMID: 38579352]
J774.A1	IC₅₀	>20 μM Compound: 3	Antiamastigote activity against promastigote stage of Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase firefly reporter gene infected in mouse J774A1 cells after 72 hrs by luminescence assay Antiamastigote activity against promastigote stage of Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase firefly reporter gene infected in mouse J774A1 cells after 72 hrs by luminescence assay	[PMID: 24858541]
MCF7	IC₅₀	27 μM Compound: 7	Cytotoxicity against human MCF7 cells after 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs	[PMID: 10075742]
MCF7	IC₅₀	4.7 μM Compound: 7	Inhibition of phorbol ester-induced ornithine decarboxylase in human MCF7 cells after 6 hrs Inhibition of phorbol ester-induced ornithine decarboxylase in human MCF7 cells after 6 hrs	[PMID: 10075742]
RAW264.7	IC₅₀	10.2 μM Compound: Table 4, R8C1	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells	[PMID: 32208222]
THP-1	CC₅₀	76.25 μM Compound: 2	Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 26906638]
THP-1	IC₅₀	23.02 μM Compound: 2	Antileishmanial activity against intracellular amastigote stage of Leishmania amazonensis infected in human THP1 cells after 3 hrs by microplate based assay Antileishmanial activity against intracellular amastigote stage of Leishmania amazonensis infected in human THP1 cells after 3 hrs by microplate based assay	[PMID: 26906638]

In Vitro

4-Hydroxylonchocarpin (7.5-30 μM) reduces the oxidation activity of L-DOPA in B16F10 cells in a dose-dependent manner^[1].
4-Hydroxylonchocarpin (15 μM, pretreated for 30 min-3 h) reduces α-MSH and IBMX-induced tyrosinase activity in B16F10 cells^[1].
4-hydroxylonchocarpin causes hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction in HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

B16F10, SKMEL and MNT-1
Concentration:

15 μM
Incubation Time:

pretreated 30 min, 1 or 3 h
Result:

The expression of tyrosinase induced by IBMX or α-MSH was significantly reduced.
MITF expression at the protein level was reduced.
Reversed the decrease in AKT and GSK3β phosphorylation due to IMBX and α-MSH treatment.

RT-PCR^[1]

Cell Line:

B16F10, SKMEL and MNT-1
Concentration:

15 μM
Incubation Time:

pretreated 1 or 3 h
Result:

Expression of Tyrp1 and Dct/Tyrp2 was downregulated even in the presence of IBMX.
MITF expression at the mRNA level was reduced.
Inhibited the promoter activity of tyrosinase and MITF.

Cell Viability Assay^[2]

Cell Line:

HepG2
Concentration:

16, 32, 48, 64, 80, 96, 112, and 128 μM
Incubation Time:

24 h
Result:

16 and 32 μM had little effect on cell viability, while cell viability decreased at higher drug concentrations.

Apoptosis Analysis^[2]

Cell Line:

HepG2
Concentration:

9, 45, and 90 μM
Incubation Time:

24 h
Result:

9 μM reduced HepG2 cells apoptosis, while 45 μM and 90 μM significantly increased apoptosis.

Chemical Information

CAS No. 56083-03-5
Appearance Solid
Masse moléculaire 322.36
Formule C₂₀H₁₈O₄
Color Yellow to orange
SMILES

O=C(C1=CC=C2C(C=CC(C)(C)O2)=C1O)/C=C/C3=CC=C(O)C=C3
Structure Classification
- Flavonoids
- Chalcones
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Pharmacol Res

Neuropilin-1 acts as a co-receptor of IL-13 to reprogram macrophages in liver fibrosis. [Abstract]

2026 Mar:225:108112. PMID: 41620153
Toxicol Lett

4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. [Abstract]

2023 Aug 15:385:31-41. PMID: 37598872

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (155.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1021 mL

15.5106 mL

31.0212 mL

5 mM

0.6204 mL

3.1021 mL

6.2042 mL

10 mM

0.3102 mL

1.5511 mL

3.1021 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (7.76 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (7.76 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (394 KB)
- English - EN (394 KB)
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- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lim J, et al. Antimelanogenic effect of 4-hydroxylonchocarpin through the inhibition of tyrosinase-related proteins and MAPK phosphatase. Exp Dermatol. 2016 Jul;25(7):574-6. [Content Brief]

[2]. Ouyang L, et al. 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. Toxicol Lett. 2023 Aug 15;385:31-41. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1021 mL	15.5106 mL	31.0212 mL	77.5530 mL
	5 mM	0.6204 mL	3.1021 mL	6.2042 mL	15.5106 mL
	10 mM	0.3102 mL	1.5511 mL	3.1021 mL	7.7553 mL
	15 mM	0.2068 mL	1.0340 mL	2.0681 mL	5.1702 mL
	20 mM	0.1551 mL	0.7755 mL	1.5511 mL	3.8777 mL
	25 mM	0.1241 mL	0.6204 mL	1.2408 mL	3.1021 mL
	30 mM	0.1034 mL	0.5170 mL	1.0340 mL	2.5851 mL
	40 mM	0.0776 mL	0.3878 mL	0.7755 mL	1.9388 mL
	50 mM	0.0620 mL	0.3102 mL	0.6204 mL	1.5511 mL
	60 mM	0.0517 mL	0.2585 mL	0.5170 mL	1.2926 mL
	80 mM	0.0388 mL	0.1939 mL	0.3878 mL	0.9694 mL
	100 mM	0.0310 mL	0.1551 mL	0.3102 mL	0.7755 mL

Keywords

4-Hydroxylonchocarpin

2 Cited Publications

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4-Hydroxylonchocarpin

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Publications Citing Use of MedChemExpress (MCE) 4-Hydroxylonchocarpin

Voir tous les produits spécifiques à Isoform p38 MAPK

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

4-Hydroxylonchocarpin Related Classifications

HY-N2208 Related Classifications