Cat. No.: HY-N0709

Coumarin

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity.

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Pureté: 99.73%
CAS No.: 91-64-5
Formule: C₉H₆O₂
Masse moléculaire:146.15

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Coumarin Chemical Structure

CAS No.: 91-64-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vivo
- Essai clinique
Chemical Information
Publications (3)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>100 μM Compound: Coumarin	Anticancer activity against human A2780 cells by CCK8 assay Anticancer activity against human A2780 cells by CCK8 assay	[PMID: 31404864]
HEL	CC₅₀	>500 μM Compound: Coumarin	Cytotoxicity against human HEL cells measured after 3 days by coulter counting method Cytotoxicity against human HEL cells measured after 3 days by coulter counting method	[PMID: 35176562]
HeLa	IC₅₀	>25 μM Compound: 10	Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique	[PMID: 20493693]
Hep 3B2	IC₅₀	>100 μM Compound: Coumarin	Anticancer activity against human Hep3B cells by CCK8 assay Anticancer activity against human Hep3B cells by CCK8 assay	[PMID: 31404864]
HepG2	IC₅₀	>100 μM Compound: Coumarin	Anticancer activity against human HepG2 cells by CCK8 assay Anticancer activity against human HepG2 cells by CCK8 assay	[PMID: 31404864]
HL-60	IC₅₀	>50 μM Compound: Coumarin	Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS	[PMID: 22901895]
MCF7	IC₅₀	>50 μM Compound: Coumarin	Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS	[PMID: 22901895]
N2a	IC₅₀	>50 μM Compound: Coumarin	Cytotoxicity against mouse Neuro2a cells after 72 hrs by WST1 assay in presence of 20% FBS Cytotoxicity against mouse Neuro2a cells after 72 hrs by WST1 assay in presence of 20% FBS	[PMID: 22901895]
OVCAR-3	IC₅₀	>100 μM Compound: Coumarin	Anticancer activity against human OVCAR3 cells by CCK8 assay Anticancer activity against human OVCAR3 cells by CCK8 assay	[PMID: 31404864]
U-937	CC₅₀	>2000 μM Compound: 1	Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs	[PMID: 18060791]
U-937	IC₅₀	>2000 μM Compound: 1	Growth inhibition of human U937 cells by [3H]thymidine incorporation assay Growth inhibition of human U937 cells by [3H]thymidine incorporation assay	[PMID: 18060791]
U-937	CC₅₀	>2 mM Compound: Coumarin	Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay	[PMID: 19716307]
U-937	IC₅₀	>400 μM Compound: Coumarin	Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting	[PMID: 19716307]
U-937	IC₅₀	>50 μM Compound: Coumarin	Cytotoxicity against human U937 cells after 72 hrs by WST1 assay in presence of 20% FBS Cytotoxicity against human U937 cells after 72 hrs by WST1 assay in presence of 20% FBS	[PMID: 22901895]
V79	IC₅₀	>100 μM Compound: coumarin	Cytotoxicity against V-79 cells Cytotoxicity against V-79 cells	10.1016/0960-894X(96)00315-0

In Vivo

Coumarin (1-10 mg/kg; p.o.) shows an antinociceptive effect in a dose-dependent manner in the acetic acid-induced writhing test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

20-25 g, Male ICR mice^[1]
Dosage:

1-10 mg/kg
Administration:

P.o.; 30 min prior to performing the acetic acid
Result:

Showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 91-64-5
Appearance Solid
Masse moléculaire 146.15
Formule C₉H₆O₂
Color White to off-white
SMILES

O=C1C=CC2=CC=CC=C2O1
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
- Plants
- Umbelliferae
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Sci Adv

Blocking the isoflavone chemoreceptor in Phytophthora sojae to prevent disease. [Abstract]

2025 Jan 10;11(2):eadt0925. PMID: 39772695
Pharmaceutics

Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy. [Abstract]

2025 Mar 26;17(4):423. PMID: 40284418
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (684.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4 mg/mL (27.37 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.8423 mL

34.2114 mL

68.4229 mL

5 mM

1.3685 mL

6.8423 mL

13.6846 mL

10 mM

0.6842 mL

3.4211 mL

6.8423 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 3 mg/mL (20.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 3 mg/mL (20.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 3 mg/mL (20.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 8.33 mg/mL (57.00 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Park SH, et al. Antinociceptive profiles and mechanisms of orally administered coumarin in mice. Biol Pharm Bull. 2013;36(6):925-30. [Content Brief]

[2]. enugopala KN, et al. Review on natural coumarin lead compounds for their pharmacological activity. Biomed Res Int. 2013;2013:963248. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	6.8423 mL	34.2114 mL	68.4229 mL	171.0571 mL
	5 mM	1.3685 mL	6.8423 mL	13.6846 mL	34.2114 mL
	10 mM	0.6842 mL	3.4211 mL	6.8423 mL	17.1057 mL
	15 mM	0.4562 mL	2.2808 mL	4.5615 mL	11.4038 mL
	20 mM	0.3421 mL	1.7106 mL	3.4211 mL	8.5529 mL
	25 mM	0.2737 mL	1.3685 mL	2.7369 mL	6.8423 mL
DMSO	30 mM	0.2281 mL	1.1404 mL	2.2808 mL	5.7019 mL
	40 mM	0.1711 mL	0.8553 mL	1.7106 mL	4.2764 mL
	50 mM	0.1368 mL	0.6842 mL	1.3685 mL	3.4211 mL
	60 mM	0.1140 mL	0.5702 mL	1.1404 mL	2.8510 mL
	80 mM	0.0855 mL	0.4276 mL	0.8553 mL	2.1382 mL
	100 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7106 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Coumarin

3 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Coumarin

Activité biologique

Chemical Information

Publications (3)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Coumarin Related Classifications

HY-N0709 Related Classifications