Cat. No.: HY-N0109

Salidroside

(Synonyms: Rhodioloside)

46 Cited Publications

Avis client

Based on 46 publication(s) in Google Scholar

Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

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Pureté: 99.88%
CAS No.: 10338-51-9
Formule: C₁₄H₂₀O₇
Masse moléculaire:300.30

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Salidroside Chemical Structure

CAS No.: 10338-51-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (46)
Solvant et solubilité
- In Vitro
- In Vivo
Protocole
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[2]

mTOR

Voir tous les produits spécifiques à Isoform mTOR :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	10.493 μM Compound: Sal	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 34978808]
MDA-MB-231	IC₅₀	40 μM Compound: 2	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 33650861]
PC-12	EC₅₀	0.21 μM Compound: Salidroside	Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells	[PMID: 31924497]
PC-12	EC₅₀	0.21 μM Compound: Salidroside	Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability	[PMID: 32738992]
PC-12	EC₅₀	0.3 μM Compound: Cpd i	Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay	[PMID: 33097301]

In Vitro

Salidroside (100 μM) inhibits prolyl endopeptidase (PEP) activity (10.6±1.9%). Prolyl endopeptidase is an enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory^[1].
Salidroside, one of the major phenylpropanoid glycosides found in R.?rosea L, is consumed almost daily as a nutritional supplement in many countries and has been identified possessing potential anti-fatigue and anoxia,anti-aging, and anti-Alzheimer's disease activities. Salidroside can improve muscle nutrition via increasing mTOR, p-mTOR, and MyHC expression^[2].
SH-SY5Y cells are exposed to 0-600?μM MPP+ for 12-48?h and the results show that MPP+ results in a significant decrease of cell viability in a concentration and time-dependent manner. Cells are pretreated with 25-100?μM Salidroside (Sal) for 24?h and then exposed to 500?μM MPP+ for an additional 24?h. Salidroside concentration-dependently prevents MPP+-induced decrease of cell viability. Annexin V/PI staining is a common method for the detection of apoptotic cell. Salidroside significantly decreases the number of Annexin V/PI-stained cells treated by MPP+ which is in a concentration-dependent manner. Apoptotic cell could also be morphologically evaluated by Hoechst staining. In Hoechst staining, apoptotic cells are characterized by reduced nuclear size, chromatin condensation, intense fluorescence, and nuclear fragmentation. Salidroside notably inhibits MPP+-induced increase of chromatin condensation, intense fluorescence, and nuclear fragmentation in SH-SY5Y cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. Salidroside (100 mg/kg/day) shows strong glucose lowering effect on db/db mice which is similar to effect of Metformin (200 mg/kg/day)^[4].
Salidroside can be used to induce testicular injury model in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 10338-51-9
Appearance Solid
Masse moléculaire 300.30
Formule C₁₄H₂₀O₇
Color White to yellow
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCCC2=CC=C(O)C=C2
Synonyms

Rhodioloside
Structure Classification
- Phenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (46)

All Cell Imaging/StainingHistological Imaging/StainingIFWB

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Journal Impact Factor

Cell Metab

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining. [Abstract]

2025 Apr 1;37(4):824-841.e8. PMID: 39879982
Nat Commun

Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice. [Abstract]

2025 Jan 2;16(1):72. PMID: 39747922

Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72. [Abstract]

Live-cell imaging analysis tracking the growth of blood vessels of Tek-CreERT2;mTmG follicles from 12-month-old females with Sal (Salidroside, 50 μM), Ft1, Dosk or vehicle.

Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72. [Abstract]

Tip cells on growing follicles after 7 days of Sal (Salidroside, 300 mg/kg BW, once a day) or vehicle treatment (left), quantifying the number of tip cells (right) showing a significant increase in tip cells on growing follicles after 7 days of Sal treatment (n = 5).

Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72. [Abstract]

Intensity of Evans blue (arrowheads) in ovaries (left) of 12-month-old females after Sal (Salidroside, 300 mg/kg BW, once a day) or vehicle treatment. Quantification of the EB signal (right) indicating Sal treatment significantly increased the blood supply to the ovaries (n = 4).

Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72. [Abstract]

Ovarian morphology with or without Sal treatment (Salidroside, 300 mg/kg BW, once a day) at 12 months, exhibiting an increase in the number of growing follicles (arrows) in the Sal group compared to the control (n = 5 mice).

Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72. [Abstract]

Immunostaining detection of proliferating granulosa cells (red: BrdU, blue: Hoechst) in Sal (Salidroside, 300 mg/kg BW, once a day) and vehicle-treated ovaries at 12 months post-PMSG treatment. Statistical analysis revealing a significantly increase in GC proliferating ratio after Sal treatment compared to the control (n = 5).
Chem Eng J

1 May 2022, 135115.
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2025 Nov 29:150:157633. PMID: 41351983
Phytomedicine

Salidroside facilitates neuroprotective effects in ischemic stroke by promoting axonal sprouting through promoting autophagy. [Abstract]

2024 Nov 9:135:156208. PMID: 39550919
Phytomedicine

Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway. [Abstract]

2022 May:99:153964. PMID: 35180677
Phytother Res

Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia. [Abstract]

2024 Jun;38(6):2619-2640. PMID: 38488455
Free Radic Biol Med

BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1. [Abstract]

2024 Mar:214:54-68. PMID: 38311259
Int J Oncol

Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway. [Abstract]

2019 Jun;54(6):1969-1980. PMID: 31081055

Salidroside purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2019 Jun;54(6):1969-1980. [Abstract]

Apoptosis‑related protein expression in MG63 cells in response to various concentrations of Salidroside is detected via western blot analysis.
Pharmaceuticals (Basel)

Salidroside Selectively Binds to SEC23A and Ameliorates Psychological Stress-Induced Hyperpigmentation. [Abstract]

2026 Mar 16;19(3):487. PMID: 41901332
Eur J Pharmacol

Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy. [Abstract]

2024 Apr 15:969:176459. PMID: 38438063
Int Immunopharmacol

Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice. [Abstract]

2023 Apr:117:109975. PMID: 36948107
Int Immunopharmacol

Salidroside suppresses group 2 innate lymphoid cell-mediated allergic airway inflammation by targeting IL-33/ST2 axis. [Abstract]

2020 Apr;81:106243. PMID: 32070919
Mol Neurobiol

Salidroside-Pretreated Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Blood-Spinal Cord Barrier Repair After Spinal Cord Injury in Mice. [Abstract]

2025 Nov 19;63(1):89. PMID: 41261280
Invest Ophthalmol Vis Sci

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis. [Abstract]

2021 Jul 1;62(9):25. PMID: 34269814
Invest Ophthalmol Vis Sci

Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure. [Abstract]

2019 May 1;60(6):2072-2082. PMID: 31091314
Front Pharmacol

CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling. [Abstract]

2020 Nov 11;11:580407. PMID: 33343350
Front Cell Dev Biol

Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress. [Abstract]

2021 Nov 10;9:763864. PMID: 34858986
Microchem J

2026 Mar 6.
Sci Rep

Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit apoptosis. [Abstract]

2025 Jul 26;15(1):27294. PMID: 40715275
Sci Rep

Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. [Abstract]

2024 Mar 30;14(1):7548. PMID: 38555283
Eur J Med Res

Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension. [Abstract]

2024 Aug 17;29(1):423. PMID: 39152472
J Dairy Sci

Salidroside protects bovine hepatocytes against fatty acid-induced lipid accumulation and inflammation by activating AMPK/SIRT1 pathway. [Abstract]

2025 Sep;108(9):10136-10150. PMID: 40645487
Cell Signal

METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs. [Abstract]

2025 May 15:111873. PMID: 40381973
Mol Cell Biochem

Salidroside overcomes cisplatin resistance in ovarian cancer via the inhibition of CRNDE-mediated autophagy. [Abstract]

2025 May;480(5):3097-3116. PMID: 39636431
J Inflamm Res

Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats. [Abstract]

2025 Oct 27:18:14857-14869. PMID: 41181365
iScience

Natural senolytic activity of Rhodiola rosea extract alleviates age-associated phenotypes via paraptosis. [Abstract]

2026 Apr 4;29(5):115607. PMID: 42028013
Biosci Rep

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion. [Abstract]

2023 Aug 31;43(8):BSR20230539. PMID: 37530723
Chem Res Toxicol

Salidroside Inhibits α-Amanitin-Induced AML-12 Cell Apoptosis via the Regulation of PINK1/Parkin-Mediated Mitophagy and Mitochondrial Function. [Abstract]

2024 Jun 17;37(6):1053-1061. PMID: 38847154
Naunyn Schmiedebergs Arch Pharmacol

Synthesizing network pharmacology, bioinformatics, and in vitro experimental verification to screen candidate targets of Salidroside for mitigating Alzheimer's disease. [Abstract]

2025 Apr;398(4):4539-4558. PMID: 39503755
Neurotox Res

Tubuloside B Alleviates Aβ25-35 Induced PC12 Cell Injury by Attenuating Pyroptosis, Apoptosis and Excessive Autophagy. [Abstract]

2026 Mar 19;44(2):12. PMID: 41854817
Toxicol Appl Pharmacol

Salidroside suppresses hypoxia-induced ocular angiogenesis by modulating the acetylation of PFKFB3 protein in endothelial cells and regulating glycolytic activity. [Abstract]

2026 Jun 23:514:117921. PMID: 42336299
Cardiovasc Toxicol

Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway. [Abstract]

2023 Dec;23(11-12):406-418. PMID: 37740139
Arch Physiol Biochem

Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats. [Abstract]

2024 Jun;130(3):257-274. PMID: 35061559
Exp Eye Res

A multi-omics study reveals molecular characteristics and therapeutic targets of salidroside in reducing TGF-β2-induced ECM expression. [Abstract]

2025 Apr 9:110386. PMID: 40216062
Exp Eye Res

MicroRNA-210-3p mediates trabecular meshwork extracellular matrix accumulation and ocular hypertension - Implication for novel glaucoma therapy. [Abstract]

2023 Feb:227:109350. PMID: 36566010
Theriogenology

Enhancing porcine oocyte quality and embryo development through natural antioxidants. [Abstract]

2025 Jan 15:232:96-108. PMID: 39536623
Urolithiasis

Salidroside attenuates calcium oxalate-induced renal injury via suppression of PANoptosis. [Abstract]

2026 Jan 2;54(1):25. PMID: 41483174
Korean J Physiol Pharmacol

Salidroside attenuates sepsis-induced acute lung injury by inhibiting ferroptosis-dependent pathway. [Abstract]

2024 Nov 1;28(6):549-558. PMID: 39467718
Exp Ther Med

Salidroside inhibits renal ischemia/reperfusion injury‑induced ferroptosis by the PI3K/AKT signaling pathway. [Abstract]

2023 Sep 14;26(5):507. PMID: 37822587
Curr Med Sci

Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel by Regulating the Wnt/β-catenin Signaling Pathway. [Abstract]

2025 Feb;45(1):104-113. PMID: 40014194
Mol Cell Toxicol

2026 Jan 20.
Res Sq

2024 May 22.
Heliyon

Salidroside attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II through inhibition of LOXL2-TGF-β1-Smad2/3 pathway. [Abstract]

2023 Oct 20;9(11):e21220. PMID: 37920527
Research Square Preprint

2021 Sep.
Oxid Med Cell Longev

Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy. [Abstract]

2020 Jul 23;2020:3549704. PMID: 32774670

Solvant et solubilité

In Vitro:

H₂O : 125 mg/mL (416.25 mM; Need ultrasonic)

DMSO : 100 mg/mL (333.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3300 mL

16.6500 mL

33.3000 mL

5 mM

0.6660 mL

3.3300 mL

6.6600 mL

10 mM

0.3330 mL

1.6650 mL

3.3300 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (333.00 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protocole

Cell Assay^[3]

SH-SY5Y cells are seeded in 96-well plates at 1×10⁴ cells per well. After the treatment with Salidroside (25-100?μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500?μg/mL MTT at 37°C for 4?h. After that, the medium is removed and 150?μL DMSO is added and shaking is conducted for 10?min. Absorbance is measured at 570?nm in a microplate reader and the results are expressed as folds of control^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[4]

Mice^[4]
The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100 mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100 mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (394 KB)
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- Swedish - SV (394 KB)
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- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fan W, et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. [Content Brief]

[2]. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. [Content Brief]

[3]. Chen X, et al. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activatingmTOR signalling. J Cachexia Sarcopenia Muscle. 2016 May;7(2):225-32. [Content Brief]

[4]. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542. [Content Brief]

[5]. Li R, et al. Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxid Med Cell Longev. 2019 Sep 10;2019:9341018. [Content Brief]

[6]. Wang Z, et al. Salidroside Ameliorates Furan-Induced Testicular Inflammation in Relation to the Gut-Testis Axis and Intestinal Apoptosis. J Agric Food Chem. 2023 Nov 9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.3300 mL	16.6500 mL	33.3000 mL	83.2501 mL
	5 mM	0.6660 mL	3.3300 mL	6.6600 mL	16.6500 mL
	10 mM	0.3330 mL	1.6650 mL	3.3300 mL	8.3250 mL
	15 mM	0.2220 mL	1.1100 mL	2.2200 mL	5.5500 mL
	20 mM	0.1665 mL	0.8325 mL	1.6650 mL	4.1625 mL
	25 mM	0.1332 mL	0.6660 mL	1.3320 mL	3.3300 mL
	30 mM	0.1110 mL	0.5550 mL	1.1100 mL	2.7750 mL
	40 mM	0.0833 mL	0.4163 mL	0.8325 mL	2.0813 mL
	50 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6650 mL
	60 mM	0.0555 mL	0.2775 mL	0.5550 mL	1.3875 mL
	80 mM	0.0416 mL	0.2081 mL	0.4163 mL	1.0406 mL
	100 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8325 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Salidroside

46 Cited Publications

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Salidroside

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High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Amino Acid Metabolite Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

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