TUG-891
Based on 14 publication(s) in Google Scholar
TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.47%
- CAS No.: 1374516-07-0
- Formule: C23H21FO3
- Masse moléculaire:364.41
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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GPCR/G Protein Compound Library
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Lactylation Compound Library
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Publications Citing Use of MedChemExpress (MCE) TUG-891
More- MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
- Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126553. [Abstract]
- Neurotherapeutics. 2025 Sep 6:e00735. [Abstract]
- Neural Regen Res. 2023 Oct;18(10):2278-2284. [Abstract]
- Front Immunol. 2021 Jun 10:12:703914. [Abstract]
- Biochem Pharmacol. 2024 Dec;230(Pt 1):116575. [Abstract]
- J Nutr Biochem. 2025 Jan:135:109772. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2026 May 29. [Abstract]
- Animals (Basel). 2025 Nov 26;15(23):3418. [Abstract]
- Anticancer Drugs. 2025 Nov 5. [Abstract]
- Biochem Biophys Res Commun. 2024 Jun 27:727:150322. [Abstract]
- Biomed Chromatogr. 2020 Sep;34(9):e4870. [Abstract]
- Research Square Print. 2022 May.
- Rapid Commun Mass Spectrom. 2020 Jun 15;34(11):e8766. [Abstract]
Customer Validation & Images
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Histological Imaging/Staining
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ELISA
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WB
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IF
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Cell Proliferation/Viability Assay
Activité biologique
TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1374516-07-0
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Appearance Solid
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Masse moléculaire 364.41
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Formule C23H21FO3
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Color White to off-white
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SMILES
O=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (14)
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Journal Impact Factor
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Most Recent
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MedComm (2020)
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4. [Abstract]2025 Aug 29;6(9):e70345. PMID: 40895192
TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
H&E staining indicated the alleviating effect of Ffar4 on CS‐induced emphysema, with reduced lung destruction and lower MLI in Ffar4‐overexpressing mice and TUG891 (35 mg/kg, p.o.)‐treated mice compared to the CS group.
TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
ELISA analysis of BALF supernatant demonstrated markedly reduced levels of proinflammatory factors IL‐6, KC, and IL‐1β in the AAV‐Ffar4+CS group and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) group.
TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
Senescent markers including p53, p21, and p‐Rb were notably downregulated in the AAV‐Ffar4+CS and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) groups compared to the AAV‐NC+CS group.
TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
Immunofluorescence results also indicated a significant decrease in P53 and P21 levels in the airway epithelium of the AAV‐Ffar4+CS and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) groups compared to the AAV‐NC+CS group.
TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345. [Abstract]
CCK8 results of TUG891 (0., 2.5, 5, 10, 20 μM) with different concentrations in HBE cells for 1 or 24 h.
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Int J Biol Macromol
2023 Dec 31;253(Pt 1):126553. PMID: 37657572 -
Neurotherapeutics
The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway. [Abstract]2025 Sep 6:e00735. PMID: 40915963 -
Neural Regen Res
TUG-891 inhibits neuronal endoplasmic reticulum stress and pyroptosis activation and protects neurons in a mouse model of intraventricular hemorrhage. [Abstract]2023 Oct;18(10):2278-2284. PMID: 37056148 -
Front Immunol
Regulation of Free Fatty Acid Receptor 4 on Inflammatory Gene Induced by LPS in Large Yellow Croaker ( Larimichthys crocea). [Abstract]2021 Jun 10:12:703914. PMID: 34177969 -
Biochem Pharmacol
Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR120. [Abstract]2024 Dec;230(Pt 1):116575. PMID: 39396646 -
J Nutr Biochem
A natural small molecule pinocembrin resists high-fat diet-induced obesity through GPR120-ERK1/2 pathway. [Abstract]2025 Jan:135:109772. PMID: 39313008 -
Naunyn Schmiedebergs Arch Pharmacol
Label-free cell phenotypic profiling of sphingosine-1-phosphate receptor 1 and discovery of its agonist from natural products. [Abstract]2026 May 29. PMID: 42209736 -
Animals (Basel)
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling. [Abstract]2025 Nov 26;15(23):3418. PMID: 41375476 -
Anticancer Drugs
Activation of the caspase-1/gasdermin D pathway via α-linolenic acid-mediated GPR120 signaling induces pyroptosis and suppresses ovarian cancer tumor growth. [Abstract]2025 Nov 5. PMID: 41191783 -
Biochem Biophys Res Commun
FFAR-mediated signaling drives migration of pancreatic cancer cells in hypoxic fibroblast co-cultures. [Abstract]2024 Jun 27:727:150322. PMID: 38945064 -
Biomed Chromatogr
Simultaneous determination of TUG-891 and its metabolites in rat plasma using LC-HRMS with application to preclinical pharmacokinetic study. [Abstract]2020 Sep;34(9):e4870. PMID: 32346871 -
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Rapid Commun Mass Spectrom
Characterization of the metabolites of TUG-891 in rat, dog, and human hepatocytes using ultra-high-performance liquid chromatography tandem mass spectrometry and nuclear magnetic resonance spectroscopy. [Abstract]2020 Jun 15;34(11):e8766. PMID: 32108961
Solvant et solubilité
DMSO : ≥ 180 mg/mL (493.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% Saline
Solubility: 5.26 mg/mL (14.43 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7442 mL | 13.7208 mL | 27.4416 mL | 68.6040 mL |
| 5 mM | 0.5488 mL | 2.7442 mL | 5.4883 mL | 13.7208 mL | |
| 10 mM | 0.2744 mL | 1.3721 mL | 2.7442 mL | 6.8604 mL | |
| 15 mM | 0.1829 mL | 0.9147 mL | 1.8294 mL | 4.5736 mL | |
| 20 mM | 0.1372 mL | 0.6860 mL | 1.3721 mL | 3.4302 mL | |
| 25 mM | 0.1098 mL | 0.5488 mL | 1.0977 mL | 2.7442 mL | |
| 30 mM | 0.0915 mL | 0.4574 mL | 0.9147 mL | 2.2868 mL | |
| 40 mM | 0.0686 mL | 0.3430 mL | 0.6860 mL | 1.7151 mL | |
| 50 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3721 mL | |
| 60 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1434 mL | |
| 80 mM | 0.0343 mL | 0.1715 mL | 0.3430 mL | 0.8576 mL | |
| 100 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6860 mL |
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