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Cat. No.: HY-119889

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A1B11

A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases.

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CAS No.: 1602731-56-5
Formule: C₂₂H₂₅N₅O
Masse moléculaire:375.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

A1B11 Chemical Structure

CAS No.: 1602731-56-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases^[1].

IC₅₀ & Target

^[1]

SIRT2

5.3 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Sirtuin :

Chemical Information

CAS No. 1602731-56-5
Masse moléculaire 375.47
Formule C₂₂H₂₅N₅O
SMILES

O=C(C1=CC=CC=C1NC2=CC=CC(C3=CN(N=N3)CCC4CCCC4)=C2)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tatum P R, et al. Identification of novel SIRT2-selective inhibitors using a click chemistry approach[J]. Bioorganic & medicinal chemistry letters, 2014, 24(8): 1871-1874. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Protocole
Pureté et documentation
Références

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Cat. No.:
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A1B11

Voir tous les produits spécifiques à Isoform Sirtuin

Activité biologique

Description

IC50 & Target

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

A1B11 Related Classifications

HY-119889 Related Classifications

Bioz

Keywords

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