Copy Link Print Information

AC-4-130

8 Cited Publications
Avis client

Based on 8 publication(s) in Google Scholar

AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.93%
  • CAS No.: 1834571-82-2
  • Formule: C37H36ClF5N2O5S
  • Masse moléculaire:751.20
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • AC-4-130 Chemical Structure
    AC-4-130 Chemical Structure
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
  • Experimental Validation Results for AC-4-130
CAS No.: 1834571-82-2
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Solvant et solubilité
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) AC-4-130

More
Customer Validation & Images
OthersHistological Imaging/StainingWBRT-PCR
  • Others
  • Histological Imaging/Staining
  • Others
  • WB
  • RT-PCR

Voir tous les produits spécifiques à Isoform STAT

More
Keywords
MOQ
Minimum order quantity
100 mg

Obtenir un devis En stock

Other size
Obtenir un devis
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • AC-4-130 Chemical Structure
    AC-4-130 Chemical Structure
    1/16
  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Sep 1. [Abstract]

    Customer Validation
     HEK-BlueTM IL-2 cells were transfected with STATeLight5A and incubated with indicated STAT5 inhibitors (10 μM AC-4-130) for 2 hours. Subsequently, cells were stimulated with 3.5 µg of IL-2 for 30 min. mNG fluorescence lifetime was measured.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Nov 14:107499. [Abstract]

    Customer Validation
     Ten⁶ MFC cells were subcutaneously injected into 615 mice (n=6 per group), followed by intraperitoneal injection of AC-4-130 (25 mg/kg), anti-PD-1 (10 mg/kg), or AC-4-130 + anti-mPD-1, for a total of 5 treatment cycles, each lasting 21 days (AC-4-130 administered daily, anti-PD-1 administered every 4 days). Ki67 staining was performed on the subcutaneous gastric cancer model.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2023 Aug;4(8):1193-1209. [Abstract]

    Customer Validation
     HSCs were sorted from 10–13-week-old WT mice and cultured for 16 h with STAT1 (NSC 118218 phosphate, 10 µM), STAT3 (BP-1-102, 5 µM) or STAT5 (AC-4-130, 5 µM) inhibitor, or vehicle.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2022 Oct 25;18(10):e1010913. [Abstract]

    Customer Validation
     Splenic leukocytes were stimulated with recombinant IL-2 for 12 hours in the presence of the STAT5 inhibitor AC-4-130 (5 mM). The expression levels of the molecules were detected by Western blotting.

  • 1/16

    AC-4-130 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2022 Oct 25;18(10):e1010913. [Abstract]

    Customer Validation
     Splenic leukocytes were stimulated with recombinant IL-2 for 12 hours in the presence of the STAT5 inhibitor AC-4-130 (5 mM). The expression levels of the molecules were detected by qPCR.

  • AC-4-130