Ametantrone
(Synonyms: NSC 196473; NSC 290813)
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Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break.
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- Pureté: 97.28%
- CAS No.: 64862-96-0
- Formule: C22H28N4O4
- Masse moléculaire:412.48
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Activité biologique
Description
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break[1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
1108 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/Dx(RI)
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/Dx(RI)
|
[PMID: 10479282] |
| A2780 | IC50 |
180 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
|
[PMID: 10479282] |
| DU-145 | IC50 |
1020 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
|
[PMID: 10479282] |
| HeLa | IC50 |
0.17 μg/mL
Compound: ametantrone
|
In vitro cytotoxicity against HeLa S3 cell lines
In vitro cytotoxicity against HeLa S3 cell lines
|
[PMID: 2213837] |
| HeLa | IC50 |
0.9 μM
Compound: Ametantrone
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 27521587] |
| HeLa | IC50 |
0.9 μM
Compound: Ametantrone
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 28342691] |
| HeLa | EC50 |
0.17 μg/mL
Compound: 2
|
Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
|
[PMID: 3172129] |
| HeLa | ED50 |
3.1 mM
Compound: AM
|
Effective concentration against cell growth of HeLa cell line by 50%
Effective concentration against cell growth of HeLa cell line by 50%
|
[PMID: 8759632] |
| HL-60 | IC50 |
15.9 nM
Compound: Ametantrone
|
Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
|
[PMID: 10479282] |
| HL-60 | GI50 |
29 nM
Compound: AT, ametantrone
|
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
|
[PMID: 17962028] |
| HL-60 | ED50 |
0.88 mM
Compound: AM
|
Effective concentration against cell growth of HL60 cell line by 50%
Effective concentration against cell growth of HL60 cell line by 50%
|
[PMID: 8759632] |
| HL60/MX2 | GI50 |
430 nM
Compound: AT, ametantrone
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Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
|
[PMID: 17962028] |
| K562 | IC50 |
12392 nM
Compound: Ametantrone
|
Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
|
[PMID: 10479282] |
| K562 | IC50 |
181 nM
Compound: Ametantrone
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Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
|
[PMID: 10479282] |
| L1210 | IC50 |
146 nM
Compound: Ametantrone
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Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
|
[PMID: 10479282] |
| L1210 | IC50 |
1.77 μg/mL
Compound: ametantrone
|
In vitro inhibitory activity against murine L1210 leukemia
In vitro inhibitory activity against murine L1210 leukemia
|
[PMID: 1732555] |
| L1210 | IC50 |
3.65 μM
Compound: ametantrone
|
In vitro inhibitory activity against murine L1210 leukemia
In vitro inhibitory activity against murine L1210 leukemia
|
[PMID: 1732555] |
| L1210 | EC50 |
0.21 g/mL
Compound: ametantrone
|
Effective concentration against inhibition of L1210 mouse leukemia cells in tissue culture
Effective concentration against inhibition of L1210 mouse leukemia cells in tissue culture
|
[PMID: 1995874] |
| L1210 | ED50 |
2.54 μg/mL
Compound: 1 (ametantrone)
|
Concentration required to inhibit the growth of L1210 leukemia cells
Concentration required to inhibit the growth of L1210 leukemia cells
|
[PMID: 2754697] |
| L1210 | EC50 |
1.77 μg/mL
Compound: 2
|
Effective concentration required to inhibit by 50% the growth of L1210 cells
Effective concentration required to inhibit by 50% the growth of L1210 cells
|
[PMID: 3172129] |
| L1210 | IC50 |
0.03 μg/mL
Compound: 1a (Ametantrone)
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Tested in vitro for inhibitory activity against L1210 murine leukemia
Tested in vitro for inhibitory activity against L1210 murine leukemia
|
[PMID: 8145234] |
| L1210 | EC50 |
275 nM
Compound: AME
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Concentration of compound required to inhibit the cellular protein biosynthesis by 50%
Concentration of compound required to inhibit the cellular protein biosynthesis by 50%
|
[PMID: 8421288] |
| L1210 | ED50 |
0.1 mM
Compound: AM
|
Effective concentration against cell growth of L1210 cell line by 50%
Effective concentration against cell growth of L1210 cell line by 50%
|
[PMID: 8759632] |
| LoVo | IC50 |
36802 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/DX(RI)
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/DX(RI)
|
[PMID: 10479282] |
| LoVo | IC50 |
641 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
|
[PMID: 10479282] |
| LoVo | IC50 |
5.8 x 10-7 M
Compound: Ametantrone
|
Inhibitory activity against human colon adenocarcinoma cell line LoVo.
Inhibitory activity against human colon adenocarcinoma cell line LoVo.
|
[PMID: 7853345] |
| LoVo | IC50 |
9.2 x 10-5 M
Compound: Ametantrone
|
Inhibitory activity against human colon adenocarcinoma cell line LoVo/Dx.
Inhibitory activity against human colon adenocarcinoma cell line LoVo/Dx.
|
[PMID: 7853345] |
| LoVo | IC50 |
0.4 μg/mL
Compound: 1a (Ametantrone)
|
Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
|
[PMID: 8145234] |
| LoVo | IC50 |
34.7 μg/mL
Compound: 1a (Ametantrone)
|
Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
|
[PMID: 8145234] |
| MCF7 | GI50 |
4.97 μM
Compound: AT, ametantrone
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 17962028] |
| MCF7 | IC50 |
0.51 μM
Compound: Ametantrone
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 27521587] |
| MCF7 | IC50 |
0.51 μM
Compound: Ametantrone
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 28342691] |
| NCI-H460 | GI50 |
2.55 μM
Compound: AT, ametantrone
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
|
[PMID: 17962028] |
| PC-3 | IC50 |
1848 nM
Compound: Ametantrone
|
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
|
[PMID: 10479282] |
| PC-3 | GI50 |
8.52 μM
Compound: AT, ametantrone
|
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
|
[PMID: 17962028] |
| SF-268 | GI50 |
2.45 μM
Compound: AT, ametantrone
|
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
|
[PMID: 17962028] |
Chemical Information
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CAS No. 64862-96-0
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Appearance Solid
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Masse moléculaire 412.48
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Formule C22H28N4O4
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Color Brown to black
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SMILES
O=C1C2=C(C=CC=C2)C(C3=C(NCCNCCO)C=CC(NCCNCCO)=C13)=O
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Synonyms
NSC 196473; NSC 290813
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 1.67 mg/mL (4.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
View the Complete Stock Solution Preparation Table
Preparing Stock Solutions
View the Complete Stock Solution Preparation Table
Concentration
Solvent
Mass
1 mg
5 mg
10 mg
Concentration
Solvent
Mass
1 mM
2.4243 mL
12.1217 mL
24.2435 mL
5 mM
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10 mM
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Calculateur de molarité
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
Calculateur de dilution
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Select Batch:
Pureté:
99.98%
Assay:
99.98%
ee.:
99.98%
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Fiche technique (266 KB)
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SDS (393 KB)
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- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4243 mL | 12.1217 mL | 24.2435 mL | 60.6087 mL |
Ametantrone Related Classifications
HY-13550 Related Classifications
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