Antascomicin B
Antascomicin B is a macrocyclic natural product that binds purified human FKBP12, FKBP12.6, FKBP51, and FKBP52. Antascomicin B acts as a molecular glue that binds the FK1 domain to stabilize the FKBP51-Akt1 complex, with a Kd of 6.7 nM for human FKBP51, independent of AKT activation status and Hsp90 binding.
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- CAS No.: 164159-88-0
- Formule: C38H59NO11
- Masse moléculaire:705.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
FKBP51 6.7 nM (Kd) |
FKBP12 0.03 nM (Kd) |
FKBP52 1.2 nM (Kd) |
In Vitro
Antascomicin B binds the FK1 domain of human FKBP51 and forms additional hydrogen-bond contacts with G84 and a solvent-exposed variable region[1].
Antascomicin B stabilizes the FKBP51-Akt1 complex in HEK293T cells, enhances FKBP51 photocrosslinking and Akt1 co-immunoprecipitation, and does so independently of Hsp90 binding and AKT T308/S473 activation status[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 164159-88-0
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Masse moléculaire 705.88
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Formule C38H59NO11
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SMILES
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])[C@H]3C)=O)=O)O[C@H]([C@H](C)C[C@H]4[C@H](O)[C@](OC)(O)[C@H](O)CC4)CC[C@H](C)/C=C/CC/C=C/C3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antascomicin B Related Classifications
HY-190160 Related Classifications
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