Antimalarial agent 12
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli.
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- CAS No.: 2715225-58-2
- Formule: C26H18BrClN2O2
- Masse moléculaire:505.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>50000 nM
Compound: (R)-3b
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
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[PMID: 35300082] |
| Hepatocyte | CC50 |
>10000 nM
Compound: (R)-3b
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Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
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[PMID: 35300082] |
Chemical Information
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CAS No. 2715225-58-2
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Masse moléculaire 505.79
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Formule C26H18BrClN2O2
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SMILES
O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 12 Related Classifications
HY-143487 Related Classifications
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