Copy Link Print Information

AX-202

Avis client

Based on 1 Customer Validation

AX-202 is a humanized anti-S100A4 monoclonal antibody that neutralizes S100A4. AX-202 blocks downstream profibrotic and proinflammatory effects. AX-202 exerts antifibrotic effects in skin fibrosis. AX-202 induces regression of pre-established skin fibrosis. AX-202 modulates anti-inflammatory and antifibrotic transcriptional pathways. AX-202 inhibits STAT3 phosphorylation. AX-202 induces AMPK and CASQ1 expression. AX-202 modulates SSc-related transcriptional signatures. AX-202 reduces tenascin-C, a DAMP and endogenous TLR4 ligand. AX-202 can be used for the research of systemic sclerosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté : 98.91%
  • Masse moléculaire:145.56 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for AX-202
  • Experimental Validation Results for AX-202
  • AX-202 Chemical Structure
    AX-202 Chemical Structure
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
AX-202 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Protocole
  • Pureté et documentation
  • Références
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Voir tous les produits spécifiques à Isoform Myosin

More

Voir tous les produits spécifiques à Isoform STAT

More

Keywords

MOQ
Minimum order quantity
100 mg

Obtenir un devis En stock

Other size
Obtenir un devis
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling AX-202 (HY-P991363, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized N-hFChuS100A4 can bind AX-202. The EC50 for this effect is 55.38 ng/mL.

  • AX-202 Chemical Structure
    1/16
  • AX-202
  • Flow cytometric analysis of 1X106 Jurkat cells labeling AX-202 (HY-P991363, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized N-hFChuS100A4 can bind AX-202. The EC50 for this effect is 55.38 ng/mL.