S100A4 - S100 calcium binding protein A4 Gene

Also Known as 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6275

About S100A4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,543,621-153,545,806 (from NCBI)

This gene has 6 transcripts (splice variants), 364 orthologues and 21 paralogues. Broad expression in lung (RPKM 268.4), bone marrow (RPKM 235.9) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

S100A4 Products (2)

mRNA	Protein	Name
NM_002961.3	NP_002952.1	protein S100-A4
NM_019554.3	NP_062427.1	protein S100-A4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RAGE receptor binding	IPI IPI: Inferred from physical interaction	15033494	GOA
enables chemoattractant activity	IDA IDA: Inferred from direct assay	26654597	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20421509	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14640694	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15033494	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	26654597	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12118070	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15033494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A4 Protein Structure

S_100

0
101 a.a.

Protein Preferred Names	Protein Names
protein S100-A4	S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)

S100A4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A4	P26447	CACYBP	Homo sapiens	Q9HB71	FPS	31837246
Intra	S100A4	P26447	EZR	Homo sapiens	P15311	FPS	31837246
Intra	S100A4	P26447	EZR	Homo sapiens	P15311	ITC	31837246
Intra	S100A4	P26447	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A4	P26447	EGFR	Homo sapiens	P00533	SPR	30083275
Intra	S100A4	P26447	EGFR	Homo sapiens	P00533	Crosslink	30083275
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	Solution Sedimentation	20421509
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	Anti Tag CoIP	33961781
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	Fluorescence Spectr	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	SPR	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	CD	22460785
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	Light Scattering	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	FPS	31837246
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	ITC	22460785
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	GMS	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	X-Ray Diffraction	22460785
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	NMR	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	ITC	22483112
Intra	S100A4	P26447	MYH9	Homo sapiens	P35579	Anti Bait CoIP	22483112
Intra	S100A4	P26447	TP53	Homo sapiens	P04637	GMS	20591429
Intra	S100A4	P26447	TP53	Homo sapiens	P04637	FPS	20591429
Intra	S100A4	P26447	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A4	P26447	TP53	Homo sapiens	P04637	PLA	23752197
Intra	S100A4	P26447	MDM2	Homo sapiens	Q00987	SPR	20591429
Intra	S100A4	P26447	MDM2	Homo sapiens	Q00987	Competition Binding	20591429
Intra	S100A4	P26447	MDM2	Homo sapiens	Q00987	GMS	20591429
Intra	S100A4	P26447	S100B	Homo sapiens	P04271	Y2H Array	32296183
Intra	S100A4	P26447	S100B	Homo sapiens	P04271	Y2H	21516116
Intra	S100A4	P26447	S100B	Homo sapiens	P04271	Y2H Prey Pooling	32296183
Intra	S100A4	P26447	BTC	Homo sapiens	P35070	Pull Down	19740107
Intra	S100A4	P26447	ERBB3	Homo sapiens	P21860	Crosslink	30083275
Intra	S100A4	P26447	ERBB3	Homo sapiens	P21860	SPR	30083275
Intra	S100A4	P26447	S100A1	Homo sapiens	P23297	Y2H Prey Pooling	32296183
Intra	S100A4	P26447	S100A1	Homo sapiens	P23297	Y2H Array	32296183
Intra	S100A4	P26447	ERBB4	Homo sapiens	Q15303	Crosslink	30083275
Intra	S100A4	P26447	ERBB4	Homo sapiens	Q15303	SPR	30083275
Intra	S100A4	P26447	AREG	Homo sapiens	P15514	SPR	30083275
Intra	S100A4	P26447	AREG	Homo sapiens	P15514	Far-WB	19740107
Intra	S100A4	P26447	AREG	Homo sapiens	P15514	Pull Down	19740107

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71140	S100A4 Protein, Human (C-His)	P26447 (M1-K101)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71140A	S100A4 Protein, Human (C/N-His)	P26447 (M1-K101)	≥ 95%, as determined by reducing SDS-PAGE.

S100A4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80317	S100A4 Antibody (YA084)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P84220	S100A4 Antibody (YA3917)	IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84220A	S100A4 Antibody (YA3917)(PBS only)	IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P85626	S100A4 Antibody (YA5318)	WB	Human
HY-P85626A	S100A4 Antibody (YA5318)(PBS only)	WB	Human
HY-P86002	S100A4 Antibody (YA5694)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Epidermoid Cysts	Epidermoid Cyst Sebaceous Cyst Epidermal Inclusion Cyst Epidermal Cyst
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Obstructive Nephropathy	Con Congenital Obstructive Nephropathy Nephropathy Obstructive
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2268	RAGE antagonist peptide	Antagonist	98.16%	Unkown
HY-168529	NU074381b	Inhibitor	98.54%	Unkown
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.41%	Unkown
HY-RS16679	S100a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12380	S100A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23114	S100a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991363	AX-202		98.91%	Unkown
HY-P990614	LK-1	Inhibitor	98.73%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	S100A4	VGNC	VGNC:34244
Macaca mulatta	S100A4	VGNC	VGNC:76958
Felis catus	S100A4	VGNC	VGNC:64840
Rattus norvegicus	S100A4	RGD	RGD:3245
Canis familiaris	S100A4	VGNC	VGNC:45830
Mus musculus	S100A4	MGD	MGI:1330282
Others	S100A4	NCBI