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Cat. No.: HY-147915

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Benz-AP

Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids.

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CAS No.: 2416220-53-4
Formule: C₂₀H₁₃NO₂
Masse moléculaire:299.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Benz-AP Chemical Structure

CAS No.: 2416220-53-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Carboxylesterase (CES) :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
A549	CC₅₀	4.4 μM Compound: Benz-AP	Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	1.6 μM Compound: Benz-AP	Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/ Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	1.4 μM Compound: Benz-AP	Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]

Chemical Information

CAS No. 2416220-53-4
Masse moléculaire 299.32
Formule C₂₀H₁₃NO₂
SMILES

O=C(NC1=C2C=CC=C3C(C=CC(C=C1)=C32)=O)C4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kailass K, et al. Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J Med Chem. 2022 Jun 14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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Benz-AP

Voir tous les produits spécifiques à Isoform Carboxylesterase (CES)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Benz-AP Related Classifications

HY-147915 Related Classifications