BMS-741672
BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5.
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- CAS No.: 1004757-96-3
- Formule: C25H33F3N6O2
- Masse moléculaire:506.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CCR2 1.1 nM (IC50) |
CCR5 780 nM (IC50) |
BMS-741672 exhibitsan IC50 of 0.67 nM for the inhibition of monocyte chemotaxis in vitro and was fully active in both monkey and hCCR2 knock-in mouse models of monocyte chemotaxis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1004757-96-3
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Masse moléculaire 506.56
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Formule C25H33F3N6O2
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SMILES
CC(N[C@H]1[C@@H](N2C([C@H](CC2)NC3=NC=NC4=C3C=C(C(F)(F)F)C=C4)=O)CC[C@H](C1)N(C)C(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-741672 Related Classifications
HY-108432 Related Classifications
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