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Cat. No.: HY-190595

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C129-0055

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 442897-27-0
Formule: C₂₅H₂₇N₃O
Masse moléculaire:385.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

C129-0055 Chemical Structure

CAS No.: 442897-27-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

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In Vitro

C129-0055 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium flux in HEK293-TRPV1 cells, with an FDSS IC₅₀ of 9.74 μM^[1].
C129-0055 (0.12-10 μM) inhibits Capsaicin-induced TRPV1 currents in HEK293-TRPV1 cells in a concentration-dependent manner, with a patch-clamp IC₅₀ of 0.95 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 442897-27-0
Masse moléculaire 385.50
Formule C₂₅H₂₇N₃O
SMILES

CC1=CC(N2CCCCC2)=NC3=C1C=C(NC(/C=C/C4=CC=C(C)C=C4)=O)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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C129-0055

Voir tous les produits spécifiques à Isoform TRP Channel

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Chemical Information

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