CGS 24012
CGS 24012 (DPMA) is a selective adenosine A2 agonist. CGS 24012 produces significant increases in cardiac output. CGS 24012 reduces renal vascular resistance to the greatest extent and produces a concomitant significant increase in renal blood flow. CGS 24012 can be used in the research of hypertension.
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- CAS No.: 120442-40-2
- Formule: C27H31N5O6
- Masse moléculaire:521.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Chemical Information
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CAS No. 120442-40-2
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Masse moléculaire 521.57
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Formule C27H31N5O6
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SMILES
N(CC(C1=CC(OC)=CC(OC)=C1)C2=C(C)C=CC=C2)C3=C4C(N(C=N4)[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)=NC=N3
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Synonyms
DPMA; PD 125944
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGS 24012 Related Classifications
HY-118229 Related Classifications
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