Cyclopentolate hydrochloride
Based on 1 Customer Validation
Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
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- Pureté: 99.54%
- CAS No.: 5870-29-1
- Formule: C17H26ClNO3
- Masse moléculaire:327.85
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model)[3]
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Dosage:20 mg/kg (Ophthalmic cyclopentolate)
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Administration:i.p.
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Result:Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%.
Chemical Information
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CAS No. 5870-29-1
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Appearance Solid
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Masse moléculaire 327.85
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Formule C17H26ClNO3
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Color White to off-white
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SMILES
O=C(OCCN(C)C)C(C1(O)CCCC1)C2=CC=CC=C2.[H]Cl
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Synonyms
DL-Cyclopentolate hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (762.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (305.02 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (305.02 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. [Content Brief]
[2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373. [Content Brief]
[3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0502 mL | 15.2509 mL | 30.5018 mL | 76.2544 mL |
| 5 mM | 0.6100 mL | 3.0502 mL | 6.1004 mL | 15.2509 mL | |
| 10 mM | 0.3050 mL | 1.5251 mL | 3.0502 mL | 7.6254 mL | |
| 15 mM | 0.2033 mL | 1.0167 mL | 2.0335 mL | 5.0836 mL | |
| 20 mM | 0.1525 mL | 0.7625 mL | 1.5251 mL | 3.8127 mL | |
| 25 mM | 0.1220 mL | 0.6100 mL | 1.2201 mL | 3.0502 mL | |
| 30 mM | 0.1017 mL | 0.5084 mL | 1.0167 mL | 2.5418 mL | |
| 40 mM | 0.0763 mL | 0.3813 mL | 0.7625 mL | 1.9064 mL | |
| 50 mM | 0.0610 mL | 0.3050 mL | 0.6100 mL | 1.5251 mL | |
| 60 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2709 mL | |
| 80 mM | 0.0381 mL | 0.1906 mL | 0.3813 mL | 0.9532 mL | |
| 100 mM | 0.0305 mL | 0.1525 mL | 0.3050 mL | 0.7625 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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