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Cat. No.: HY-P99845

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Dazodalibep

Name: Dazodalibep
Brand: MedChemExpress
SKU: HY-P99845
Price: 480.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: MEDI-4920; VIB 4920)

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Dazodalibep (MEDI 4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sjögren's syndrome.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 99.0%
CAS No.: 2245953-10-8
Masse moléculaire:87.82 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dazodalibep Chemical Structure

CAS No.: 2245953-10-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Species Reactivity
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Dazodalibep (MEDI 4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sjögren's syndrome^[1]^[2]^[3].

Isotype

Fusion - Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3) 2 TNC-F3 domains

Species Reactivity

Human

Voir tous les produits spécifiques à Isoform TNF Receptor :

In Vitro

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

Dazodalibep blocks the CD40-CD40L costimulatory interaction between T cells and CD40-expressing B cells and antigen-presenting cells^[2].
Dazodalibep blocks costimulatory signal transduction between T cells, B cells, and antigen-presenting cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Collagen-Induced Arthritis

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

959 [NCBI]

Accession

P29965

Target

TNFSF5/CD40L/CD154

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3)2 TNC-F3 domains

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2245953-10-8
Appearance Liquid
Masse moléculaire 87.82 kDa
Color Colorless to light yellow
SMILES

[Dazodalibep]
Synonyms

MEDI-4920; VIB 4920
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Bustos AH, et al. Citrullinated peptides as drug candidates for rheumatoid arthritis. Frontiers in immunology. 2025;16:1648913.

[2]. Aung T, et al. Bridging the Gap in Sjögren's Disease: A Comprehensive Review of Unmet Needs, Diagnostic Challenges, and Emerging Therapeutic Strategies. Cureus. 2026 Jul;18(7):e113186.

[3]. Palla P, et al. Infections in Sjögren's disease: a clinical concern or not?. Clinical and experimental rheumatology. 2024 Dec;42(12):2531-2541.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Isotype
- Species Reactivity
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références

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Dazodalibep

Voir tous les produits spécifiques à Isoform TNF Receptor