DNMT3A-IN-4
DNMT3A-IN-4 is a DNMT3A inhibitor with an IC50 of 33.4 μM against human DNMT3A. DNMT3A-IN-4 inhibits the proliferation of colorectal cancer cells and can be used for the research of colorectal cancer.
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- Formule: C20H15N5O3
- Masse moléculaire:373.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
DNMT3A 33.4 μM (IC50) |
In Vitro
DNMT3A-IN-4 (compound 6o) (100-320 μM; 1 h) preferentially inhibits recombinant human DNMT3A/3L over DNMT1, and shows only weak inhibitory activity against DNMT1 even at concentrations as high as 320 μM[1].
DNMT3A-IN-4 (25-150 μM; 24-72 h) does not reduce the viability of HCT116 colorectal cancer cells[1].
DNMT3A-IN-4 (100 μM; 24 h) does not reduce the protein abundance of DNMT1 or DNMT3A in HCT116 colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 373.36
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Formule C20H15N5O3
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SMILES
O=C1NC2=C(C(C3=CC=C(N4C=CN=C4)C=C3)C5=C(O2)C=C(O)C=C5)C(N)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNMT3A-IN-4 Related Classifications
HY-184332 Related Classifications
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