DPP8/9-IN-2
DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors.
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- CAS No.: 3109603-86-0
- Formule: C30H30F3N3O2
- Masse moléculaire:521.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
DPP-8 0.22 nM (IC50) |
DPP-9 3 nM (IC50) |
Nav1.5 29.0 μM (IC50) |
DPP-8 2.9 nM (Ki) |
DPP-9 6 nM (Ki) |
Chemical Information
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CAS No. 3109603-86-0
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Masse moléculaire 521.57
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Formule C30H30F3N3O2
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SMILES
O=C(N1CC2=C(C=C(F)C=C2)C1)[C@@H](N)CC(N3CCC(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DPP8/9-IN-2 Related Classifications
HY-175226 Related Classifications
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