DTP348
DTP348 is an inhibitor for carbonic anhydrase IX with a Ki of 8.3 nM in vitro and an IC50 of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with LD50 of 3.5 mM. DTP348 can be used in the anti-cancer research.
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- CAS No.: 1383370-92-0
- Formule: C6H11N5O4S
- Masse moléculaire:249.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-13513
U-104CA IX/XII Inhibitor -
HY-108316
SultiameCarbonic Anhydrase Inhibitor -
HY-B0397
DichlorphenamideCarbonic Anhydrase Inhibitor -
HY-101087
BenzenesulphonamideCA Inhibitor -
HY-B0483
TioxoloneCarbonic Anhydrase Inhibitor -
HY-13650
IndisulamCarbonic Anhydrase Inhibitor/RBM39 Molecular Glue Degrader -
HY-B1480
EthoxzolamideCarbonic Anhydrase Inhibitor -
HY-N0639
PunicalinAnti-HBV Agent -
HY-B0397R
Dichlorphenamide (Standard)Carbonic Anhydrase Inhibitor -
HY-B0553
MethazolamideCarbonic Anhydrase Inhibitor -
HY-B0483R
Tioxolone (Standard)Carbonic Anhydrase Inhibitor -
HY-108316R
Sultiame (Standard)Carbonic Anhydrase Inhibitor
Activité biologique
Description
IC50 & Target
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CA IX 8.3 nM (Ki) |
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1383370-92-0
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Masse moléculaire 249.25
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Formule C6H11N5O4S
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SMILES
O=S(NCCN1C([N+]([O-])=O)=CN=C1C)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Acute Systemic Toxicity Study
Acute systemic toxicity studies evaluate adverse effects occurring after a single exposure, or repeated exposure within a short acute window, and the main in vivo readouts are mortality, moribund condition, clinical signs, body-weight change, and gross pathological findings; acute oral toxicity methods were developed to replace classical LD50 testing with reduced-animal designs such as fixed-dose procedure, acute toxic class method, and up-and-down procedure. The fixed-dose procedure classifies acute toxicity by administering predefined dose levels and observing evident toxicity rather than using death as the primary endpoint, whereas the acute toxic class method uses sequential groups of three animals per step and the up-and-down procedure doses animals sequentially to estimate an LD50 with fewer animals than conventional LD50 testing.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DTP348 Related Classifications
HY-120367 Related Classifications
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