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Cat. No.: HY-162581

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FCPR16

FCPR16 is a Phosphodiesterase 4 (PDE4) inhibitor. FCPR16 increases the levels of cAMP in SH-SY5Y cells. FCPR16 can be used in the study of Parkinson's disease.

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CAS No.: 1917347-71-7
Formule: C₁₈H₁₆ClF₂NO₃
Masse moléculaire:367.77

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

FCPR16 Chemical Structure

CAS No.: 1917347-71-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

FCPR16 is a Phosphodiesterase 4 (PDE4) inhibitor. FCPR16 increases the levels of cAMP in SH-SY5Y cells. FCPR16 can be used in the study of Parkinson's disease^[1].

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.04 μM Compound: 9; FCPR16	Inhibition of human N-terminal GST-tagged PDE4D7 (2 to 748 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 hr by fluorescence polarization assay Inhibition of human N-terminal GST-tagged PDE4D7 (2 to 748 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 hr by fluorescence polarization assay	[PMID: 30822711]
Sf9	IC₅₀	0.17 μM Compound: 9; FCPR16	Inhibition of human full length N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate incubated for 1 hr by fluorescence polarization assay Inhibition of human full length N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate incubated for 1 hr by fluorescence polarization assay	[PMID: 30822711]

Chemical Information

CAS No. 1917347-71-7
Masse moléculaire 367.77
Formule C₁₈H₁₆ClF₂NO₃
SMILES

O=C(C1=CC=C(C(OCC2CC2)=C1)OC(F)F)NC3=CC=CC=C3Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhong J, et al. Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress. Redox Biol. 2018 Jun;16:47-58. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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FCPR16

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)