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MAL2 - mal, T cell differentiation protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114569

About MAL2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,208,363-119,245,673 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 140.3), thyroid (RPKM 100.0) and 16 other tissues.

Summary

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

MAL2 Products (1)

mRNA	Protein	Name
NM_052886.3	NP_443118.1	protein MAL2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12963375	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in membrane raft	IDA IDA: Inferred from direct assay	23264465	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAL2 Protein Structure

MARVEL

0
100
176 a.a.

Protein Preferred Names	Protein Names
protein MAL2	MAL proteolipid protein 2

MAL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MAL2	Q969L2	SH3GL1	Homo sapiens	Q6FGM0	Validated Y2H	25416956
Intra	MAL2	Q969L2	SH3GL1	Homo sapiens	Q6FGM0	Y2H Array	25416956
Intra	MAL2	Q969L2	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	MAL2	Q969L2	PBX3	Homo sapiens	Q5JS98	Y2H Array	25416956
Intra	MAL2	Q969L2	PBX3	Homo sapiens	Q5JS98	Y2H Prey Pooling	25416956
Intra	MAL2	Q969L2	VARS2	Homo sapiens	Q5ST30-3	Validated Y2H	25416956
Intra	MAL2	Q969L2	TUBB	Homo sapiens	Q5SU16	Validated Y2H	25416956
Intra	MAL2	Q969L2	TUBB	Homo sapiens	Q5SU16	Y2H Array	25416956
Intra	MAL2	Q969L2	PTPN9	Homo sapiens	Q6IQ43	Y2H Prey Pooling	25416956
Intra	MAL2	Q969L2	FAM3A	Homo sapiens	Q9BU27	Validated Y2H	25416956
Intra	MAL2	Q969L2	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	MAL2	Q969L2	TARS2	Homo sapiens	Q9BW92	Validated Y2H	32296183
Intra	MAL2	Q969L2	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	MAL2	Q969L2	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	MAL2	Q969L2	NFAM1	Homo sapiens	Q8NET5	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	NFAM1	Homo sapiens	Q8NET5	Y2H Array	32296183
Intra	MAL2	Q969L2	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	MAL2	Q969L2	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	MAL2	Q969L2	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	MAL2	Q969L2	PITPNC1	Homo sapiens	Q9UKF7-2	Validated Y2H	32296183
Intra	MAL2	Q969L2	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	MAL2	Q969L2	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	MAL2	Q969L2	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	MAL2	Q969L2	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	MAL2	Q969L2	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	MAL2	Q969L2	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	MAL2	Q969L2	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	SUCLA2	Homo sapiens	Q9P2R7	Validated Y2H	32296183
Intra	MAL2	Q969L2	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	MAL2	Q969L2	CD68	Homo sapiens	P34810	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	CD68	Homo sapiens	P34810	Y2H Array	32296183
Intra	MAL2	Q969L2	ARFIP2	Homo sapiens	P53365	Validated Y2H	25416956
Intra	MAL2	Q969L2	ARFIP2	Homo sapiens	P53365	Y2H Array	25416956
Intra	MAL2	Q969L2	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	25416956
Intra	MAL2	Q969L2	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	MAL2	Q969L2	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	MAL2	Q969L2	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
Intra	MAL2	Q969L2	TBRG4	Homo sapiens	Q969Z0	Y2H Prey Pooling	25416956
Intra	MAL2	Q969L2	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183
Intra	MAL2	Q969L2	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	32296183
Intra	MAL2	Q969L2	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	MAL2	Q969L2	PTPN9	Homo sapiens	P43378	Y2H Array	31515488
Intra	MAL2	Q969L2	GAD1	Homo sapiens	Q99259	Validated Y2H	32296183
Intra	MAL2	Q969L2	RAB37	Homo sapiens	Q96AX2	Validated Y2H	25416956
Intra	MAL2	Q969L2	RAB37	Homo sapiens	Q96AX2	Y2H Array	25416956
Intra	MAL2	Q969L2	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	MAL2	Q969L2	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	MAL2	Q969L2	MTERF3	Homo sapiens	Q96E29	Validated Y2H	32296183
Intra	MAL2	Q969L2	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	MAL2	Q969L2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	MAL2	Q969L2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	MAL2	Q969L2	GAD2	Homo sapiens	Q05329	Y2H Prey Pooling	25416956
Intra	MAL2	Q969L2	GAD2	Homo sapiens	Q05329	Y2H Array	25416956
Intra	MAL2	Q969L2	HSFX1	Homo sapiens	Q9UBD0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parasagittal Meningioma
Cerebral Convexity Meningioma	Cerebral Hemispheric Convexity Meningioma
Foster-Kennedy Syndrome	Disorder Of The Optic Nerve Optic Nerve Diseases Disease Of Optic Cranial Nerve Disease Of Optic Nerve Disease Of Second Cranial Nerve Disorder Of Optic Cranial Nerve Disorder Of Second Cranial Nerve Disorders Of 2nd Nerve
Anterior Cranial Fossa Meningioma	Meningioma Of The Anterior Fossa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-116683	116-9e	Inhibitor	98.28%	Unkown
HY-183594	Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal		/	Unkown
HY-RS07992	MAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19350	Mal2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25841	Mal2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAL2	VGNC	VGNC:84015
Mus musculus	MAL2	MGD	MGI:2146021
Canis familiaris	MAL2	VGNC	VGNC:54900
Felis catus	MAL2	VGNC	VGNC:99808
Bos taurus	MAL2	VGNC	VGNC:54901
Rattus norvegicus	MAL2	RGD	RGD:735066
Others	MAL2	NCBI