PANX1 - pannexin 1 Gene

Also Known as PX1; MRS1; OOMD7; UNQ2529

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 24145

About PANX1

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,128,841-94,181,968 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 7.4), appendix (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

PANX1 Products (1)

mRNA	Protein	Name
NM_015368.4	NP_056183.2	pannexin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP transmembrane transporter activity	IDA IDA: Inferred from direct assay	15304325	GOA
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	16908669	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32231289	GOA
enables leak channel activity	IMP IMP: Inferred from mutant phenotype	16908669	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17036048	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in ATP transport	IDA IDA: Inferred from direct assay	15304325	GOA
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	16908669	GOA
involved in monoatomic cation transport	IDA IDA: Inferred from direct assay	17036048	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	17036048	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in bleb	IDA IDA: Inferred from direct assay	17036048	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16908669	GOA
located in gap junction	IDA IDA: Inferred from direct assay	16908669	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17036048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PANX1 Protein Structure

Innexin

0
100
200
300
400
426 a.a.

Protein Preferred Names	Protein Names
pannexin-1	innexin

PANX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PANX1	Q96RD7	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	PANX1	Q96RD7	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	PANX1	Q96RD7	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PANX1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82904	Pannexin 1 Antibody (YA2649)	WB, IP	Human

Related Diseases

Diseases	Alias
Oocyte Maturation Defect 7	OOMD7 Oocyte Maturation Defect, Type 7
Female Infertility Due To Oocyte Meiotic Arrest
Intellectual Developmental Disorder, Autosomal Dominant 1	MRD1 Autosomal Dominant Non-Syndromic Intellectual Disability 1 Mental Retardation, Autosomal Dominant 1 Autosomal Dominant Intellectual Developmental Disorder 1
Vertebral Artery Occlusion	Occlusion And Stenosis Of Vertebral Artery
Anterior Spinal Artery Syndrome	Anterior Spinal Artery Occlusion Syndrome
Deafness, Autosomal Dominant 41	DFNA41 Autosomal Dominant Nonsyndromic Deafness 41 Autosomal Dominant Deafness 41 Deafness, Autosomal Dominant, 41 Deafness, Autosomal Dominant, Type 41
Infertility
Basilar Artery Occlusion
Oculodentodigital Dysplasia	Odd Syndrome ODDD Oculodentoosseous Dysplasia Oculodentodigital Syndrome Odod Oculo-Dento-Digital Dysplasia Oculo-Dento-Digital Syndrome Oculo-Dento-Osseous Dysplasia Osseous-Oculo-Dental Dysplasia Meyer-Schwickerath Syndrome Oddd Syndrome Oculo Dento Digital Dysplasia Odds Oculodentodigital Dysplasia Syndrome
Jejunoileitis
Migraine, Familial Hemiplegic, 1	FHM1 Mhp1 Fhm Familial Hemiplegic Migraine 1 Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia Migraine, Hemiplegic, Familial, Type 1 Hemiplegic Migraine, Familial Type 1
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Cerebral Arterial Disease	Cerebral Arterial Diseases
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-A0170	Trovafloxacin	Inhibitor	99.43%	Unkown
HY-103399	Trovafloxacin mesylate	Inhibitor	99.76%	Unkown
HY-B1588	Carbenoxolone	Inhibitor	99.9%	Yes

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P1137	10Panx	Inhibitor	99.34%	Unkown
HY-B1588S	Carbenoxolone-d4	Inhibitor	99.28%	Unkown
HY-P1138	Scrambled 10Panx	Inhibitor	/	Unkown
HY-RS10021	PANX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16802	Panx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23243	Panx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PANX1	VGNC	VGNC:32567
Felis catus	PANX1	VGNC	VGNC:68691
Canis familiaris	PANX1	VGNC	VGNC:44254
Macaca mulatta	PANX1	VGNC	VGNC:75754
Mus musculus	PANX1	MGD	MGI:1860055
Rattus norvegicus	PANX1	RGD	RGD:735204
Others	PANX1	NCBI